Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Bacterial reverse mutation assay: the substance 1-[(1,1-Dimethylethyl)dimethylsilyl]piperazine was negative with and without metabolic activation in S. typhimurium strains TA 98, TA100, TA1535, TA1537 and E.coli WP2uvrA (OECD TG 471) (Ceri Hita, 2012).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

1-(Tert-butyldimethylsilyl)piperazine has been tested in a valid Bacterial reverse mutation assay, conducted according to a protocol similar to OECD TG 471, and in compliance with GLP, using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and E.coli WP2uvrA. No increase in the number of revertants was observed in any test strain, with or without metabolic activation when tested up to a limit concentration. Appropriate positive and negative (solvent) controls were included and gave the expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.

Justification for classification or non-classification

Based on the available data for 1-(tert-butyldimethylsilyl)piperazine, no classification is required for genetic toxicity according to Regulation (EC) No 1272/2008.