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EC number: 249-828-6 | CAS number: 29761-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 October 1983 - 27 October 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Clear report, early GLP, similar to OECD Guideline 403
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Remarks:
- early GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Isodecyl diphenyl phosphate
- EC Number:
- 249-828-6
- EC Name:
- Isodecyl diphenyl phosphate
- Cas Number:
- 29761-21-5
- Molecular formula:
- C22H31O4P
- IUPAC Name:
- isodecyl diphenyl phosphate
- Details on test material:
- - Name of test material (as cited in study report): Santicizer 148
- Physical state: liquid
- Analytical purity: confidential
- Lot/batch No.: confidential
- Stability under test conditions: no data
- Storage condition of test material: Temperature monitored room (15.6 – 29.4 °C)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories Wilmington, Delaware 01887, USA
- Age at study initiation: Males: 9 weeks; Females: 10 weeks
- Weight at study initiation: Males- Mean: 274 g (range 246 to 303 g); Females - Mean: 229 g (range: 222 to 238 g)
- Fasting period before study: no data
- Housing: Animals were group housed in elevated stainless steel wire mesh cages during the acclimation period and individually housed during all subsequent non-exposure periods.
- Diet: ad libitum, standard laboratory diet (Purina-Rodent Laboratory Chow)
- Water: ad libitum, by automated watering system (Elizabethtown Water Company)
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.6 - 24.4
- Humidity (%): 25-76
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Plexiglass Exposure chamber
- Exposure chamber volume: 100 liter
- Method of holding animals in test chamber: no data
- Source and rate of air: flow rate: 10 l/min.
- Method of conditioning air:
- System of generating particulates/aerosols: A large three-neck round bottom flask fitted with a Laskin Aerosol Generator.
- Method of particle size determination: Particle size distribution samples were obtained using a Casella cascade impactor at approx. 1 hour intervals throughout the exposure. The distribution was calculated based on the amount of test substance collected on the impactor stages (glass slides).
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber: A thermometer and Airguide relative humidity indicator were used to record temperature and humidity in the chamber. Recordings were made at approx. hourly intervals throughout the exposure. The average chamber temperature and humidity were 25°C and 35%, resp.
TEST ATMOSPHERE
- Brief description of analytical method used:Gravimetry
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: Analysis of particle size distribution data revealed a mass median aerodynamic diameter of 2.5 microns with a geometric standard deviation of 2.4 - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- The amount and distribution of the test substance was determined gravimetrically. Particle size distribution samples were obtained using a Casella cascade impactor
- Duration of exposure:
- ca. 4 h
- Concentrations:
- Nominal exposure concentration: 13 mg/l
Mean analytical concentration (gravimetry): 6.3 mg/l - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed prior to exposure, at approximately 15 minute intervals during the first hour of exposure, hourly for the remainder of the exposure, upon removal from the chamber, and hourly for two hours post-exposure. Detailed observations were recorded at each interval. Body Weight: Day I (immediately prior to exposure) and on Days 2, 3, 5, 8 and 15 (post-exposure period).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy - Statistics:
- Not relevant
Results and discussion
- Preliminary study:
- Not relevant
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 6.3 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: No deaths. Signs exhibited during exposure: increases in secretory responses and reduced activity. Signs during the post-exposure period: incidences of secretory responses, rough coat and yellow ano-genital fur A transient decrease in body weight.
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 13 mg/L air (nominal)
- Exp. duration:
- 4 h
- Remarks on result:
- other: No deaths. Signs exhibited during exposure: increases in secretory responses and reduced activity. Signs during the post-exposure period: incidences of secretory responses, rough coat and yellow ano-genital fur A transient decrease in body weight.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Exposure observations revealed some to most animals exhibited lacrimation, salivation, chromodacryorrhea and reduced activity during the entire exposure. Upon removal from the chamber, the animals exhibited increased incidences of secretory responses (lac
- Body weight:
- Slight decreases in body weights for both sexes of animals were exhibited following exposure (Test Day 2). Most of the females had regained their pretest body weights by Test Day 3; however, all males did not regain their pretest body weights until Test Day 8. The body weights were considered unremarkable for the remainder of the post-exposure period.
- Gross pathology:
- Gross postmortem findings occurred sporadically and were not considered related to the test material.
- Other findings:
- Not relevant
Any other information on results incl. tables
Not relevant
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- A single four-hour exposure to 6.3 mg/l Santicizer 148 as a respirable aerosol mixture produced no mortality in a group of 10 rats. Signs exhibited during exposure included increases in secretory responses and reduced activity. Signs during the post-exposure period: incidences of secretory responses, rough coat and yellow ano-genital fur. A transient decrease in body weight was observed. As no deaths occurred the tested concentration can be considered as LC0. Based on these results, the test substance does not need to be classified for acute inhalation toxicity according to the criteria outlined in Annex I of 1272/2008/EC and Annex VI of 67/548/EEC.
- Executive summary:
This acute inhalation toxicity study in rats was conducted according to a method resembling OECD guideline 403. A single 4-hour exposure to 6.3 mg/l Santicizer 148 as a respirable aerosol mixture produced no mortality in a group of 5 male and 5 female Sprague-Dawley rats. Rats were observed for 14 days after exposure. Signs exhibited during exposure included increases in secretory responses and reduced activity. Incidences of secretory responses, rough coat and yellow ano-genital fur persisted during the two-week post-exposure period. A transient decrease in body weight was noted an Test Day 2. Subsequently, female body weights were unremarkable, while all males did not regain their pretest body weights until Test Day 8. Gross postmortem findings occurred sporadically and were not considered related to the test material. As no deaths occurred the tested concentration can be considered as LC0. Based on these results, the test substance does not need to be classified for acute inhalation toxicity according to the criteria outlined in Annex I of 1272/2008/EC and Annex VI of 67/548/EEC.
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