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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Tetralinvergiftung. Offizielles Protokoll der Gesellschaft der Ärzte in Wien
Author:
Arnstein A
Year:
1922
Bibliographic source:
Wien. Klin. Wschr. 21, S. 88

Materials and methods

Study type:
clinical case study

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3,4-tetrahydronaphthalene
EC Number:
204-340-2
EC Name:
1,2,3,4-tetrahydronaphthalene
Cas Number:
119-64-2
Molecular formula:
C10H12
IUPAC Name:
1,2,3,4-tetrahydronaphthalene

Method

Subjects:
- Persons: 2 painters
Examinations:
- Exposure: Painting for three days with tetralin-containing varnishes in  a poorly ventilated area

Results and discussion

Results of examinations:
- Main symptom: Dark green colored urine
- Other symptoms: intense irritation of mucous membranes, profuse  lacrimation, headache, and stupor
- Reversibility: Complete within few days

Applicant's summary and conclusion