Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats
Author:
Servé MP, Llewelyn BM, Yu KO, McDonald GM, Olson CT and Hobson DW
Year:
1989
Bibliographic source:
J. Toxicol. Environ. Health 26, 267-275
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Type of study / information:
Type: other: Nephrotoxicity and Metabolism
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3,4-tetrahydronaphthalene
EC Number:
204-340-2
EC Name:
1,2,3,4-tetrahydronaphthalene
Cas Number:
119-64-2
Molecular formula:
C10H12
IUPAC Name:
1,2,3,4-tetrahydronaphthalene
Details on test material:
1,2,3,4-Tetrahydronaphthalene from Aldrich Chemical Co., Milwaukee; metabolite standards from same source or synthesized according to procedures reported. Purities not reported.

Results and discussion

Any other information on results incl. tables

RENAL DAMAGE:
- Exposed and control female rats did not display any renal damage. 
- Male exposed rats exhibited increased cytoplasmic hyaline droplets in  proximal convoluted tubular epothelial cells, which were  indicative for  toxic injury. Additionally, foci of cellular degeneration were present  within proximal convoluted tubules. Intratubular 

cellular casts, overt  glomerular changes or significant inflammation was not seen.
METABOLITES identified (mean percentages in all 36 samples):
  1,2,3,4-tetrahydro-1-naphthol, CAS No. 529-33-9 (29 %)
  1,2,3,4-tetrahydro-2-naphthol, CAS No. 530-91-6 (7 %)
  1,2,3,4-tetrahydro-1-oxo-2-naphthol (33 %)
  1,2,3,4-tetrahydro-1-oxo-4-naphthol (25 %)
  1,2,3,4-tetrahydronaphthalene-1,4-diol (1 %)
  1,2,3,4-tetrahydronaphthalene-1,2-diol (traces)

Applicant's summary and conclusion