1,2,3,4-tetrahydronaphthalene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Documentation very brief

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1949

Report date:

1949

Reference 2

Reference Type:

publication

Title:

Range-finding toxicity data: list IV

Author:

Smyth HF Jr, Carpenter CP and Weil CS

Year:

1951

Bibliographic source:

Arch. Ind. Hyg. Occup. Med. 4, 119-122

Materials and methods

Principles of method if other than guideline:

Method: other: Smyth HF Jr, Carpenter CP (1944): The place of the range finding test in the industrial toxicology laboratory. J. Ind. Hyg. Toxicol. 26, 269-273 and subsequent updates

GLP compliance:

no

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2,3,4-tetrahydronaphthalene

EC Number:

204-340-2

EC Name:

1,2,3,4-tetrahydronaphthalene

Cas Number:

119-64-2

Molecular formula:

C10H12

IUPAC Name:

1,2,3,4-tetrahydronaphthalene

Details on test material:

tetrahydronaphthalene procured from Eastman Kodak Co. under their number P550 on 10 Jan. 1949. No data on purity

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

not specified

Details on inhalation exposure:

Animals were exposed to saturated vapor at 20°C or a mist generated at 170°C

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

ca. 1.8 mg/l and higher

No. of animals per sex per dose:

6

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LC50

Effect level:

> 1.8 mg/L air

Exp. duration:

8 h

Applicant's summary and conclusion

Conclusions:

In an inhalation experiment rats showed no mortalities at 8h exposure to saturated vapour at 20°C or a mist generated at 170°C. Thus tetrahydronaphthalene showed low acute toxicity in rats after inhalation.

Executive summary:

Groups of 6 rats each tolerated 8 hour exposure to substantially saturated vapour at room temperature (calculated at 1.8 mg tetrahydronaphthalene per litre air considering a vapour pressure of 34 Pa at 20°C) or to mist generated by aerating the compound while it was heated at 170°C (corresponding to 10.5 mg/L with a vapour pressur of 290 Pa at 170°C)