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EC number: 204-340-2 | CAS number: 119-64-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list IV
- Author:
- Smyth HF Jr, Carpenter CP and Weil CS
- Year:
- 1 951
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med. 4, 119-122
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
- Report date:
- 1949
Materials and methods
- Principles of method if other than guideline:
- Smyth HF Jr, Carpenter CP (1944): The place of the range finding test in the industrial toxicology laboratory. J. Ind. Hyg. Toxicol. 26, 269-273 and subsequent updates
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2,3,4-tetrahydronaphthalene
- EC Number:
- 204-340-2
- EC Name:
- 1,2,3,4-tetrahydronaphthalene
- Cas Number:
- 119-64-2
- Molecular formula:
- C10H12
- IUPAC Name:
- 1,2,3,4-tetrahydronaphthalene
- Details on test material:
- Tetrahydronaphthalene procured from Eastman Kodak Co. under their number P550 on 10 Jan. 1949. No data on purity
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
-male Albino Rabbbits
-Weight at study initiation: 2,202-2,718 g
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: undiluted
- Details on dermal exposure:
- ADMINISTRATION:
- Area covered: clipped trunk
- Occlusion: impervious flexible film ("vinylite" sheeting)
- Exposure period: 24 hours
- Observation period: 14 days - Duration of exposure:
- 24 hours
- Doses:
- 12.6; 15.8; 20.0 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- Thompson, W.R. (1947): Use of moving averages and interpolation to estimate median effective dose. Bact. Rev. 11, 115
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 16 800 mg/kg bw
- Mortality:
- MORTALITY:
LD50 = 17.3 (14.5 - 20.6) mL/kg bw
= 16.8 (14.1 - 20.0) g/kg bw - Clinical signs:
- other: CLINICAL SIGNS: Upon removal of the covering the skin was erythematous, on subsequent examination it was necrosed and ultimately leathery and dry.
- Gross pathology:
- Autopsy revealed pale livers and kidneys and congestion of the pancreas and intestines.
Any other information on results incl. tables
- Number of deaths at each dose:
12,600 mL/kg bw: 1/5 on day 4
15,800 mL/kg bw: 1/5 on day 13
20,000 mL/kg bw: 1+2+1/5 on days 11, 12, 14
Applicant's summary and conclusion
- Conclusions:
- The LD50 (rabbit) for tetrahydronaphthalene applied to the skin of the rabbit is 17.3 mL/kg bw (=16.8 g/kg bw). Thus tetrahydronaphthalene showed low acute toxicity in rabbits after dermal application.
- Executive summary:
The LD50 for tetrahydronaphthalene applied undiluted to the clipped skin of the rabbit trunk under "Vinylit" sheeting for 24h was 17.3 mL/kg bw (14.5 -20.6). Upon removal of the covering the the skin was erythemous, on subsequent examination it was necrosed and ultimately because leathery and dry. Autopsy of victims revealed pale livers, and kidneys and congestion of the pancreas and intestines. The disparity between oral and percutaneous toxicity indicates that tetrahydronaphthalene pentrates quite slowly through the skin.
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