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EC number: 204-340-2
CAS number: 119-64-2
Two experimental in vivo studies with rabbits reported skin
irritating effects for tetrahydronaphthalene (Hüls AG 1984, Carpenter
1949) also in a dermal toxicity study a skin irritating effect was
observed in rats (Clark, 1984). Two experimental studies with rabbits
showed no or mild and reversible eye irritation (Hüls AG 1984; Carpenter
The application of 0.01 mL of the undiluted tetrahydronaphthalene to the
clipped skin of the rabbit produced moderate to marked erythema of an
intensity comparable to that induced by 2 ethyl-hexylacetate which is
representative of grade 4 compounds.
Mild skin irritation was reported.
In an acute dermal toxicity test two male rats each received a dermal
doses of 1.8 g, 3.6 g or 7.3 g Tetrahydronaphthaline applied undiluted
to the shaved skin with unoccluded dressing for 24 h.
No adverse systemic effects were noted during 14 days observation period.
Local effects were summarised as mild skin irritation.
- Erythema: 3.11
- Edema: 1.56
- Irritation index: 4.55/8 = moderately irritant
REVERSIBILITY: not complete within 14 days
Irritant response data for each animal at
each observation time
Score at time point / Reversibility
Max. score: 4
Eschar formation for all animals
Average 24h, 48h, 72h
Not completely reversible
In a primary skin irritation test with three male and three female
rabbits tetrahydronaphthalene was applied with occlusive dressing to the
shaved back skin at a dose level of 0.5 mL per animal for 4 h. Residual
test substance was washed of with warm water. Skin reaction were scored
according to OECD criteria at 1h, 24h, 48h, 72h and 6d, 9d, 11d and 14d
In a primary eye irritation study 0.1 mL of undiluted
tetrahydronaphthalene was instilled into the conjunctival sac of one eye
of three male and three female young adult White Russian rabbits. Eyes
were not rinsed. Animals were observed for 6 days.
Cornea and iris were not affected. Slight to mild and reversible
conjunctival effects were observed. In this study,
tetrahydronaphthalene was not an eye irritant.
In a primary eye irritation study 0.5 mL of undiluted
tetrahydronaphthalene was instilled into the eye of albino rabbits.
Animals were observed for 3 days.
Cornea and iris were not affected. Very mild and reversible
conjunctival effects were observed. In this study,
tetrahydronaphthalene was not an eye irritant..
Cited from SIAR for19 (19-22 October
a study according to OECD TG 404 with rabbits (Small white Russian),
undiluted 1,2,3,4-tetrahydronaphthalene caused moderate irritation with
Draize scores of 3.11 for erythema, 1.56 for edema, and 4.55 in total.
Effects were not completely reversible within 14 days (Hüls AG, 1984 b).
irritation intensity was observed in an early and limited study
published by Smyth, Carpenter and Weil (1951) as well as by Union
Carbide Corp. (1992). They report an irritation index of 4/10 in rabbits
24 hours after application of 0.01 ml 1,2,3,4-tetrahydronaphthalene to
the clipped belly of rabbits (no information on occlusion).
skin condition similar to turpentine-induced dermatitis that was
eczematous in nature is reported in five painters (four males, one
female) that used 1,2,3,4-tetrahydronaphthalene (1 case) or mixtures
containing 1,2,3,4-tetrahydronaphthalene as substitutes for turpentine.
From the rare occurrence of the symptoms, the author concluded that the
persons probably had a high sensitivity (Galewsky, 1922).
a study according to OECD TG 405 with rabbits (Small white Russian),
undiluted 1,2,3,4-tetrahydronaphthalene caused no significant irritation
with Draize scores of 5.17/110. Effects were completely reversible
within 6 days (Hüls AG, 1984 a). Similar irritation intensity was
observed in an early study published by Smyth, Carpenter and Weil (1951)
as well as by Union Carbide Corp. (1992). They report an irritation
index of 1/10 in rabbits 18-24 hours after application of 0.5 ml
1,2,3,4-tetrahydronaphthalene to rabbits (not rinsed).
painters who had been painting for three days with
1,2,3,4-tetrahydronaphthalene-containing varnishes in a poorly
ventilated area complained, among others, about irritation of mucous
membranes and profuse lacrimation (Arnstein, 1922).
were no studies available in animals or humans
1,2,3,4-Tetrahydronaphthalene was a
moderate irritant to the skin (OECD TG 404) but not to the eye (OECD TG
405). However, high exposure from the gas phase may cause irritation of
mucous membranes and profuse lacrimation in humans.
Effects on skin irritation/corrosion: irritating
All available data for skin corrosion/irritation showed that
tetrahydronaphthalene has to be classified as skin irritant. Based on
our study data for eye irritation, tetrahydronaphthalene does not
require classification and labelling as eye irritant (Hüls AG, 1984).
However, according to classification according to Annex VI of CLP
regulation 1272/2008, tetrahydronaphthalene was classified as eye
irritant Cat. 2.
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