Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2021
Report date:
2021

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-{2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]propane-1,3-diyl}bis(1H-1,2,4-triazole)
EC Number:
928-141-1
Molecular formula:
C16H20F2N6OSi
IUPAC Name:
1,1'-{2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]propane-1,3-diyl}bis(1H-1,2,4-triazole)

Results and discussion

Water solubility
Key result
Water solubility:
0.418 g/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
25 °C
pH:
6.38

Applicant's summary and conclusion

Conclusions:
The water solubility of Silyl-fluconazole is 0.41838 g/l.