Registration Dossier
Registration Dossier
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EC number: 928-141-1 | CAS number: -
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 d
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1'-{2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]propane-1,3-diyl}bis(1H-1,2,4-triazole)
- EC Number:
- 928-141-1
- Molecular formula:
- C16H20F2N6OSi
- IUPAC Name:
- 1,1'-{2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]propane-1,3-diyl}bis(1H-1,2,4-triazole)
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Type of inoculum: aerobic mixed bacterial culture
Source: Municipal wastewater treatment plant, Esztergom-Kertváros
Date of arriving: 03 July 2017 - Duration of test (contact time):
- 28 d
- Details on study design:
- Aerobic biodegradation of the test item was determined by measuring oxygen consumption in an inoculum containing aerobic mixed bacterial culture originated from a municipal wastewater treatment plant and maintained at laboratory conditions. The bacterial culture was not adapted to the test item.
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
- Test performance:
- This study was performed to evaluate the ready biodegradability of Silyl-fluconazole in an aerobic aqueous medium. The study was performed according to OECD 301 guideline for testing chemicals (Ready Biodegradability), method F: Manometric Respirometry
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Remarks on result:
- other: mean of two replicates)
Applicant's summary and conclusion
- Conclusions:
- According to OECD guideline the test item should be classified as readily biodegradable if the percentage biodegradation reaches 60% of theoretical oxygen demand within 28 day period in a 10-day window. Based on ready biodegradability testing results the Silyl-fluconazole is not readily biodegradable
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