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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The test was conducted by means of Read Across approach. Further information was attached at section 13

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
- Principle of test: single oral administration
- Observation period: 7 days
- Parameters analysed / observed: mortality
GLP compliance:
no
Remarks:
Pre 1981

Test material

Constituent 1
Reference substance name:
Similar Substance 01 - ABr165:1
IUPAC Name:
Similar Substance 01 - ABr165:1
Test material form:
not specified

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
- Concentration in vehicle: 3 to 35 % suspension in 0.5 % CMC solution.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality observed.
Clinical signs:
Dyspnea, feces blackened, some animals showed diarrhea and slight apathy.
Body weight:
Slight weight loss towards the end of the study .
Gross pathology:
No abnormalities detected.

Applicant's summary and conclusion

Interpretation of results:
other: CLP Criteria not met
Conclusions:
LD50 > 10000 mg/kg b.w.
Executive summary:

Rats were exposed to a single oral dose of the test item, which followed a period of observation of 7 days.

No mortality was recorded; no significant clinical signs or organ abnormalities were recorded.

Conclusion

LD50 > 10000 mg/kg b.w.