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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The test was conducted by means of Read Across approach. Further information was attached at section 13

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
- Principle of test: single oral administration
- Observation period: 7 days
- Parameters analysed / observed: mortality
GLP compliance:
no
Remarks:
Pre 1981

Test material

Constituent 1
Reference substance name:
Similar Substance 01 - ABr165:1
IUPAC Name:
Similar Substance 01 - ABr165:1
Test material form:
not specified

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
- Concentration in vehicle: 3 to 35 % suspension in 0.5 % CMC solution.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality observed.
Clinical signs:
other: Dyspnea, feces blackened, some animals showed diarrhea and slight apathy.
Gross pathology:
No abnormalities detected.

Applicant's summary and conclusion

Interpretation of results:
other: CLP Criteria not met
Conclusions:
LD50 > 10000 mg/kg b.w.
Executive summary:

Rats were exposed to a single oral dose of the test item, which followed a period of observation of 7 days.

No mortality was recorded; no significant clinical signs or organ abnormalities were recorded.

Conclusion

LD50 > 10000 mg/kg b.w.