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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1975
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The test was conducted by means of Read Across approach. Further information was attached at section 13

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
- Principle of test: inhalation of an atmosphere saturated with vapor at 20 °C.
- Short description of test conditions: saturation conducted through a layer of 5 cm of the test item.
- Parameters analysed / observed: mortality.
GLP compliance:
no
Remarks:
Pre 1981

Test material

Constituent 1
Reference substance name:
Similar Substance 01 - ABr165:1
IUPAC Name:
Similar Substance 01 - ABr165:1
Test material form:
not specified

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation: aerosol
Details on inhalation exposure:
- Time of exposure: 3, 10, 30 minutes and 1, 3, 8 hours.

Results and discussion

Effect levels
Exp. duration:
8 h
Remarks on result:
other: no death occurred
Mortality:
No deaths occurred.
Gross pathology:
No abnormalities observed.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
After 8 hours exposure, no mortality was observed and no abnormalities at necropsy were noted.
Executive summary:

An inhalation acute toxicity study was conducted on rats. Exposure occurred by inhalation of an atmosphere saturated with vapor, conducted through a layer of 5 cm of the test item.

No deaths occurred at the highest exposure time of 8 hours, however, no indication regarding the exposure concentration was present. For this reason, the performed study is not suitable for classification purpose.