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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients.
Author:
D. Belsito , D. Bickers , M. Bruze , P. Calow , M.L. Dagli , A.D. Fryer ,H. Greim , Y. Miyachi , J.H. Saurat , I.G. Sipes
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S269–S313

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mention below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of Phenethyl butyrate on rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethyl butyrate
EC Number:
203-119-8
EC Name:
Phenethyl butyrate
Cas Number:
103-52-6
Molecular formula:
C12H16O2
IUPAC Name:
2-phenylethyl butyrate
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Smiles notation: c1(CCOC(CCC)=O)ccccc1
- InChl: 1S/C12H16O2/c1-2-6-12(13)14-10-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3
- Substance type:Organic

Specific details on test material used for the study:
- Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Substance type:Organic
- Physical state:Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
4600 mg/kg bw
No. of animals per sex per dose:
Total: 10 animals = 4600 mg/kg bw
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 600 mg/kg bw
Based on:
test mat.
95% CL:
4 200 - 5 000
Remarks on result:
other: 50% mortality was observed in treated rats at 4600 mg/kg bw
Mortality:
50% mortality was observed in treated rats at 4600 mg/kg bw
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 4600 mg/kg bw (4200–5000 mg/kg bw) with 95% Confidence interval of 4200–5000 mg/kg ,when rats were treated with Phenethyl butyrate (103-52-6) orally.
Executive summary:

The Acute oral toxicity study was done in 10 rats using test material Phenethyl butyrate (103-52-6).50% mortality was observed in treated rats at 4600 mg/kg bw.Hence,LD50 value was considered to be 4600 mg/kg bw with 95% Confidence interval of 4200–5000 mg/kg,when rats were treated with Phenethyl butyrate (103-52-6)orally.