Registration Dossier
Registration Dossier
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EC number: 231-246-9 | CAS number: 7460-74-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients.
- Author:
- D. Belsito , D. Bickers , M. Bruze , P. Calow , M.L. Dagli , A.D. Fryer ,H. Greim , Y. Miyachi , J.H. Saurat , I.G. Sipes
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology 50 (2012) S269–S313
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of Phenethyl butyrate on rats.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- Phenethyl butyrate
- EC Number:
- 203-119-8
- EC Name:
- Phenethyl butyrate
- Cas Number:
- 103-52-6
- Molecular formula:
- C12H16O2
- IUPAC Name:
- 2-phenylethyl butyrate
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Smiles notation: c1(CCOC(CCC)=O)ccccc1
- InChl: 1S/C12H16O2/c1-2-6-12(13)14-10-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Substance type:Organic
- Physical state:Liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 4600 mg/kg bw
- No. of animals per sex per dose:
- Total: 10 animals = 4600 mg/kg bw
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 200 - 5 000
- Remarks on result:
- other: 50% mortality was observed in treated rats at 4600 mg/kg bw
- Mortality:
- 50% mortality was observed in treated rats at 4600 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 4600 mg/kg bw (4200–5000 mg/kg bw) with 95% Confidence interval of 4200–5000 mg/kg ,when rats were treated with Phenethyl butyrate (103-52-6) orally.
- Executive summary:
The Acute oral toxicity study was done in 10 rats using test material Phenethyl butyrate (103-52-6).50% mortality was observed in treated rats at 4600 mg/kg bw.Hence,LD50 value was considered to be 4600 mg/kg bw with 95% Confidence interval of 4200–5000 mg/kg,when rats were treated with Phenethyl butyrate (103-52-6)orally.
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