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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients.
Author:
D. Belsito , D. Bickers , M. Bruze , P. Calow , M.L. Dagli , A.D. Fryer ,H. Greim , Y. Miyachi , J.H. Saurat , I.G. Sipes
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S269–S313

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mention below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of Phenethyl butyrate on rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethyl butyrate
EC Number:
203-119-8
EC Name:
Phenethyl butyrate
Cas Number:
103-52-6
Molecular formula:
C12H16O2
IUPAC Name:
2-phenylethyl butyrate
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Smiles notation: c1(CCOC(CCC)=O)ccccc1
- InChl: 1S/C12H16O2/c1-2-6-12(13)14-10-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3
- Substance type:Organic

Specific details on test material used for the study:
- Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Substance type:Organic
- Physical state:Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
4600 mg/kg bw
No. of animals per sex per dose:
Total: 10 animals = 4600 mg/kg bw
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 600 mg/kg bw
Based on:
test mat.
95% CL:
4 200 - 5 000
Remarks on result:
other: 50% mortality was observed in treated rats at 4600 mg/kg bw
Mortality:
50% mortality was observed in treated rats at 4600 mg/kg bw
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 4600 mg/kg bw (4200–5000 mg/kg bw) with 95% Confidence interval of 4200–5000 mg/kg ,when rats were treated with Phenethyl butyrate (103-52-6) orally.
Executive summary:

The Acute oral toxicity study was done in 10 rats using test material Phenethyl butyrate (103-52-6).50% mortality was observed in treated rats at 4600 mg/kg bw.Hence,LD50 value was considered to be 4600 mg/kg bw with 95% Confidence interval of 4200–5000 mg/kg,when rats were treated with Phenethyl butyrate (103-52-6)orally.