Registration Dossier
Registration Dossier
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EC number: 272-599-9 | CAS number: 68892-13-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- For 28 June 2016 to September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.24 Partition Coefficient (1-Octanol/Water): Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method
- Version / remarks:
- March 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- April 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- August 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.2
- Temp.:
- 35 °C
- Remarks on result:
- other: neutral pH
- Key result
- Type:
- log Pow
- Partition coefficient:
- 6.5
- Temp.:
- 35 °C
- Remarks on result:
- other: neutral pH
- Details on results:
- 95.64% of test item components possess a log Kow between 4.2 and 6.5.
- Conclusions:
- The log of partition coefficient of the test item is higher than 4.
Two values have been found, one for each main constituent of the test item - Executive summary:
The test item partition coefficient was determined with HPLC method according to recognised guidelines and under GLP.
No deviation from these guidelines was observed during the study.
The log of partition coefficient of the test item is found higher than 4.
The test item is considered to potentially bioaccumulable.
Reference
The main test has been performed using HPLC method with UV detection. Using this method, several peaks were observed. In order to identify the main constituents of the test item, the analysis was repeated using HPLC with mass detection.
The calibration curve built with the references substances allow the determination of Log Kow between 1.1 to 7.2. The values found for the test item are included in this range.
Description of key information
The test item partition coefficient was determined in an experimental key study (Klimisch validity one, according to recognised guidelines).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.5
- at the temperature of:
- 20 °C
Additional information
The log of partition coefficient of the test item is found higher than 4. 95.64% of test item components possess a log Kow between 4.2 and 6.5.
The test item is considered to potentially bioaccumulable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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