Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
This study was conducted between 20 September 2016 and 20 January 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study is considered to be a reliability 1 as it has been conducted according to OECD TG 105 using the column elution method and in compliance with GLP.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
27 July 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
EC NO. 440/2008 of 30 May 2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Key result
Water solubility:
ca. 0.33 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
0.326 mg/L
Incubation duration:
> 2 h
Temp.:
20 °C
pH:
> 6.3 - < 7.8
Details on results:
Preliminary test:
The preliminary estimate of water solublity was <0.26 mg/L at 20”C.

Definitive test:

The mean peak heights relating to the standard and sample solutions are shown in table below.

 Solution  Mean Peak Area x 105
 Standard 0.162 mg/L  1.6808
 Standard 0.158 mg/L  1.3417
Blank Solution  None detected
 System A 1A  1.4407
 System A 1B  1.4129
 System B 1A  0.84288
 System B 1B  0.0571
 System A 2A  1.2300
 System A 2B  1.2268
 System B 2A  1.2745
 System B 2B  1.2444
 Standard 0.152 mg/L  1.3339
 Standard 0.152 mg/L  1.4016
 Blank Solution  None detected
 System A 3A  1.1150
 System A 3B  1.3159
 System B 3A  1.1362
 System B 3B  1.8198
 Standard 0.151 mg/L  1.5176
 Standard 0.152 mg/L  1.3980
 Blank Solution

 None detected
 System A 4A  2.3858
 System A 4B  1.9389
 System B 4A  2.1302
 System B 4B  2.2788
 Standard 0.155 mg/L  1.5578
 Standard 0.187 mg/L  1.5010
 Blank Solution

 None detected
 System A 5A  2.0245
 System A 5B  1.8095
 System B 5A  1.5900
 System B 5B  1.8940
 Standard 0.151 mg/L  1.2536
 Standard 0.154 mg/L  1.6505
 System A 6A  1.0576
 System A 6B  1.3583
 System B 6A  1.3631
 System B 6B  2.0155

The concentration (g/l) of test material in the sample solutions is shown in the table below.

 Sample number  Sampling Time (hour)    Concentration (g/L x 10-4)     Solution pH   
   System A  System B  System A  System B  System A  System B
 1  112.25  112.25  3.03  2.02  6.9  6.3
 2  119.25  119.25  2.61  2.68  6.5  6.8
 3  136.25  136.25  2.70  328  7.8  6.8
 4  160.25  160.25  4.49  4.58  6.3  6.7
 5  184.28  184.25  4.02  3.61  6.4  6.6
 6  208.25  208.25  2.54  3.56  6.3  6.7
Conclusions:
The water solubility of the test item l was determined to be 0.33 mg/L @ 20 ± 0.5 °C using OECD TG 105 (Water solubility) using the column elution method in compliance with GLP.

Executive summary:

The water solubility of the test item was determined to be 0.33 mg/L @ 20 °C using OECD TG 105 and according to GLP, using the column elution method.

Description of key information

The water solubility of the test item l was determined to be 0.33 mg/L @ 20 ± 0.5 °C using OECD TG 105 (Water solubility) using the column elution method in compliance with GLP.

Key value for chemical safety assessment

Water solubility:
0.33 mg/L
at the temperature of:
20 °C

Additional information