Registration Dossier
Registration Dossier
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EC number: 206-922-1 | CAS number: 400-38-4
Endpoint summary
Administrative data
Description of key information
Isopropyl trifluoroacetate appeared to be not irritating to the skin, while it induced eye irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin irritation:
Based on the results on an in vitro EPISKINTM(SM) model test, isopropyl trifluoroacetate is non-irritant to skin. Therefore no classification for skin irritation is warrented according to Regulation (EC) 1272/2008 (CLP).
Eye irritation:
Based on the results of an in vitro eye irritation assay in isolated chicken eyes, isopropyl trifluoroacetate is not classified as a severe irritant and not classified as non-irritant. Since information is required to conclude on the classification, an in-vivo eye irritation study with the substance Ethyl Trifluoroacetate (Guillot, 1983) was used in an analogue approach. Ethyl Trifluoroacetate (CAS 383-63-1) was identified as an analogue of isopropyl trifluoroacetate based on the similarity of its structure (ethyl group or isopropyl group bound to trifluoroacetic acid) and the fact that both compounds hydrolyse rapidly to the common degradation product trifluoroacetic acid.
Based on the results of this study, Ethyl trifluoroacetate is classified as Eye Irr. 2 (Causes serious eye irritation, H319) according to Regulation (EC) 1272/2008 (CLP). Since the effects are reversible within 7 days, subcategory 2B is applied according to the GHS UN criteria. The same classification is applied for isopropyl trifluoroacetate.
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