Registration Dossier
Registration Dossier
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EC number: 904-551-6 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study is carried out predating current guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of 1-(2,6,6-trimethylcyclohex-2-en-1-yl)hepta-1,6-dien-3-one and 1-(2,6,6-trimethylcyclohex-1-en-1-yl)hepta-1,6-dien-3-one
- EC Number:
- 904-551-6
- Molecular formula:
- C16H24O
- IUPAC Name:
- Reaction mass of 1-(2,6,6-trimethylcyclohex-2-en-1-yl)hepta-1,6-dien-3-one and 1-(2,6,6-trimethylcyclohex-1-en-1-yl)hepta-1,6-dien-3-one
- Test material form:
- liquid
1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 3 (intact skin)
3 (abraded skin) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed within the 14 day observation period.
- Other findings:
- Dry cracked skin was noted.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- According to Regulation (EC) No. 1272/2008.
- Conclusions:
- The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw
- Executive summary:
A preguideline study was performed to identify the acute dermal toxicity of the test substance.In this study 3 albino rabbits were administered with 5000 mg/kg neat test substance on the intact skin. The animals were exposed for 24 hours under occlusive conditions. No mortality was observed within the 14 -day observation period. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/kg bw.
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