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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Study is carried out predating current guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
Reaction mass of 1-(2,6,6-trimethylcyclohex-2-en-1-yl)hepta-1,6-dien-3-one and 1-(2,6,6-trimethylcyclohex-1-en-1-yl)hepta-1,6-dien-3-one
EC Number:
904-551-6
Molecular formula:
C16H24O
IUPAC Name:
Reaction mass of 1-(2,6,6-trimethylcyclohex-2-en-1-yl)hepta-1,6-dien-3-one and 1-(2,6,6-trimethylcyclohex-1-en-1-yl)hepta-1,6-dien-3-one
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
5000 mg/kg
No. of animals per sex per dose:
3 (intact skin)
3 (abraded skin)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed within the 14 day observation period.
Other findings:
Dry cracked skin was noted.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Remarks:
According to Regulation (EC) No. 1272/2008.
Conclusions:
The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw
Executive summary:

A preguideline study was performed to identify the acute dermal toxicity of the test substance.In this study 3 albino rabbits were administered with 5000 mg/kg neat test substance on the intact skin. The animals were exposed for 24 hours under occlusive conditions. No mortality was observed within the 14 -day observation period. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/kg bw.