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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Test start date: 13 February, 1990; Test end date: 21 May, 1990; Study completion date: 25 June, 1990
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Code number of the test material as used in the study report: Methine Blue TRL; FAT 31064/F
According to the analytical certificate the test compound consists to about 50 % of the cationic acetate. The other half is in the hydrolyzed OH form (carbinol base).
- Source and lot No.of test material: EN 158496.82/ HEW 133/6
Analytical method:
photometric method
Key result
Type:
log Pow
Partition coefficient:
0.99
Temp.:
25 °C
pH:
2.1
Type:
Pow
Partition coefficient:
9.8
Temp.:
25 °C
pH:
2.1
Conclusions:
The n-octanol/water partition coefficent of the test item at 25 °C was determined to be (log Pow) 0.99.
Executive summary:

A test was conducted to determine the n-octanol/water partition coefficient of the test substance according to the OECD Guideline 107 and EU Method A.8. The shake flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition coefficent of the test item at 25 °C, from the individual solubility in water and n-octanol, was determined to be (log Pow) 0.99.

Description of key information

A test was conducted to determine the n-octanol/water partition coefficient of the test substance according to the OECD Guideline 107 and EU Method A.8. The shake flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition coefficent of the test item at 25 °C, from the individual solubility in water and n-octanol, was determined to be (log Pow) 0.99.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.99
at the temperature of:
25 °C

Additional information