Registration Dossier
Registration Dossier
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EC number: 200-752-1 | CAS number: 71-41-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Food flavorings and compounds of related structure I. Acute Oral Toxicity
- Author:
- Jenner PM et al.
- Year:
- 1 964
- Bibliographic source:
- Food Cosmet. Toxicol. 2, 327-343
- Reference Type:
- secondary source
- Title:
- Toxicity and metabolsim of industrial solvents
- Author:
- Browning E
- Year:
- 1 973
- Bibliographic source:
- Med. Res. Council Ind. Health Res. Board,Rep.No. 80, H.M. Stationery Office, London
- Reference Type:
- secondary source
- Title:
- 1-Pentanol
- Author:
- Rowe VK and McCollister SB
- Year:
- 1 982
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology, 3rd rev. ed., Wiley, New York, pp. 4527–4708
- Reference Type:
- secondary source
- Title:
- Die Situation in der gesundheitlichen Beurteilung der Aromatisierungsmittel fur Lebensmittel
- Author:
- Bär VF and Griepentrog F
- Year:
- 1 967
- Bibliographic source:
- Medizin Ernahr., 8, 244-251
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Amyl alcohol (pentanol)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALSTEST ANIMALS
- Fasting period before study: 18 hours
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- no data
- No. of animals per sex per dose:
- 5
- Control animals:
- other: other substances
- Details on study design:
- - Duration of observation period following administration: 14 days
Other examinations performed: clinical signs, mortality - Statistics:
- LD50 values were calculated per Litchfield-Wilcoxon (1949)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 030 mg/kg bw
- 95% CL:
- 1 440 - 6 360
- Remarks on result:
- other: slope = 1.2 (1.0 - 1.4)
- Mortality:
- Death from a few minutes to 18 hours
- Clinical signs:
- other: Depression
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
