Registration Dossier
Registration Dossier
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EC number: 200-752-1 | CAS number: 71-41-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- For justification of read across please refer to section 13.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Jr. HF et al.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Ass. J., 23, 95-107
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 008
- Bibliographic source:
- RIFM database
Materials and methods
- Principles of method if other than guideline:
- modified acc. to Draize, J.H. et al., J. Pharmacol. Exp. Therap. 82, 377 (1944)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylbutan-1-ol
- EC Number:
- 205-289-9
- EC Name:
- 2-methylbutan-1-ol
- Cas Number:
- 137-32-6
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-Methylbutanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- Type of wrap if used: impervious plastic film
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 value and its fiducial range are estimated by the method of Thompson (1947) using the Tables of Weil (1952)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.54 mL/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 860 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: density = 0.808 g/cm3
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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