Registration Dossier
Registration Dossier
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EC number: 200-752-1 | CAS number: 71-41-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Screening procedures for the experimental cancer chemotherapy
- Author:
- Szybalski W
- Year:
- 1 958
- Bibliographic source:
- Ann. N.Y. Acad. Sci. 76 (3), 475-489
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 009
- Bibliographic source:
- RIFM database
Materials and methods
- Principles of method if other than guideline:
- paper-disk method acc. to Iyer VN. and Szybalski W, Appl. Microbiol. 6, 23-29, 1958
- GLP compliance:
- no
- Type of assay:
- bacterial gene mutation assay
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): n-amyl alcohol
Constituent 1
Method
- Target gene:
- streptomycin dependence
Species / strain
- Species / strain / cell type:
- other: Escherichia coli Sd-4-73
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 10 - 25 µl/plate (paper-disk-method)
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: several concurrent positive experiments
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: as impregnation on paper disk
DURATION
- Preincubation period: overnight culture
SELECTION AGENT (mutation assays): Streptomycin
Results and discussion
Test results
- Species / strain:
- other: Escherichia coli Sd-4-73
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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