Registration Dossier
Registration Dossier
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EC number: 203-223-3 | CAS number: 104-65-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance material review on Cinnamyl formate
- Author:
- S.P. Bhatia, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S70–S73
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials: Cinnamyl formate
- Author:
- D. L. J. Opdyke
- Year:
- 1 976
- Bibliographic source:
- Food and Cosmetics Toxicology,Volume 14, Supplement, Pages 659-893 (1976)
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
- Author:
- D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007) S1–S23
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute Dermal Toxicity test was carried out to study the effects of Cinnamyl formate (104-65-4) on rabbits.
- GLP compliance:
- no
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- Cinnamyl formate
- EC Number:
- 203-223-3
- EC Name:
- Cinnamyl formate
- Cas Number:
- 104-65-4
- Molecular formula:
- C10H10O2
- IUPAC Name:
- cinnamyl formate
- Details on test material:
- - Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Cinnamyl formate
- Molecular formula :C10H10O2
- Molecular weight:162.187 g/mol
- Substance type:Organic
- Physical state:Colorless to slightly yellow liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- Duration of exposure : 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Total: 6 animals = 5000 mg/kg bw
- Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed in treated rabbits at 5000 mg/kg bw
- Mortality:
- No mortality was observed in treated rabbits at 5000 mg/kg bw
- Clinical signs:
- other: No clinical effects were observed
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 value was considered to be >5000 mg/kg bw,when 6 rabbits were treated occlusively with Cinnamyl formate (104-65-4) by dermal application for exposure of 24 hours.
- Executive summary:
In acute dermal toxicity study, 6 Rabbits were treated with Cinnamyl formate (104-65-4) in the concentration of 5000 mg/kg bw by dermal application. No mortality was observed in treated rabbits at dose 5000 mg/kg bw.No clinical effects were observed.Therefore, LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated occlusively with Cinnamyl formate (104-65-4) by dermal application for exposure of 24 hours.
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