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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journals .

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw material monograph of cinnamyl formate
Author:
D. L. J. Opdyke
Year:
1972
Bibliographic source:
food and chemical toxicology 1972
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007) S1–S23

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate the skin irritation potential of Cinnamyl formate on human male volunteers
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl formate
EC Number:
203-223-3
EC Name:
Cinnamyl formate
Cas Number:
104-65-4
Molecular formula:
C10H10O2
IUPAC Name:
cinnamyl formate
Details on test material:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid
Specific details on test material used for the study:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid

Test animals

Species:
other: human
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petroletum
Controls:
not specified
Amount / concentration applied:
4%
Duration of treatment / exposure:
48hrs
Observation period:
48hrs
Number of animals:
5 male volunteers
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No skin reaction were observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritant
Conclusions:
Cinnamyl formate when applied on 5 male volunteers gave no skin reaction. Cinnamyl formate was considered to be not irritating to human skin.
Executive summary:

Cinnamyl formate was used as a test material for maximization pre-test to evaluate it’s skin irritation potential on 5 male volunteers .

The test material was used in the concentration of 4% in petrolatum ,

No skin reactions were observed.Cinnamyl formate was considered to be not irritating to human skin.