Registration Dossier
Registration Dossier
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EC number: 946-357-4 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (Z)-2-(8-heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol
- EC Number:
- 244-501-4
- EC Name:
- (Z)-2-(8-heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol
- Cas Number:
- 21652-27-7
- Molecular formula:
- C22H42N2O
- IUPAC Name:
- 2-(2-heptadec-8-en-1-yl-4,5-dihydro-1H-imidazol-1-yl)ethanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 0.1 ml of the test substance were applied into the conjunctival sac of the left eye of each animal. The right eye was not treated and served as control. The treated eye of animals 4-6 was cautiously rinsed with 10 ml luke warm water after 4 seconds of application.
- Observation period (in vivo):
- 1 hour; observation was stopped after 1 hour due to severe effects in the eye.
- Number of animals or in vitro replicates:
- 6 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 3
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Application of 0.1 ml (Z)-2-(8-Heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol into the conjuncival sac of White New Zealand rabbits caused severe eye damage.
- Executive summary:
An acute eye irritation test according to OECD Guideline 405 was carried out with (Z)-2-(8-Heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol in White New Zealand rabbits. The substance caused severe eye damage.
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