Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case reports
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Anecdotal reports of effects of exposure of methyl pyridines.

Data source

Reference
Reference Type:
secondary source
Title:
3-Methylpyridine: Human toxicity excerpts
Author:
Anonymous
Year:
2010
Bibliographic source:
Hazardous Substances Data Base(HSDB), ToxNet, http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rYtOpf:1

Materials and methods

Study type:
other: case reports
Endpoint addressed:
not applicable
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
case reports of exposures
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methylpyridine
EC Number:
203-636-9
EC Name:
3-methylpyridine
Cas Number:
108-99-6
Molecular formula:
C6H7N
IUPAC Name:
3-methylpyridine

Method

Type of population:
occupational
Ethical approval:
not applicable
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Any other information on results incl. tables

3-METHYLPYRIDINE
CASRN: 108-99-6


Human Toxicity Excerpts:
CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF PYRIDINE INCL WT LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS. /PICOLINES/


POISONING IN 32 YR OLD MALE INDUST EXPOSED TO VAPORS WAS CHARACTERIZED BY AUTONOMIC DISTURBANCES AGAINST ASTHENIC BACKGROUND (ANGIODYSTONIA, TENDENCY TOWARD HYPOTONIA & BRADYCARDIA, INCR OF PILOMOTOR REFLEX, & DISTURBANCES OF THERMOREGULATION) & BY POLYNEURITIC PHENOMENA.


A 58 YR OLD MAN OCCUPATIONALLY EXPOSED TO BETA-PICOLINE FOR 11 YR SHOWED AN INCR IN LIVER GLUTAMIC PYRUVIC TRANSAMINASE & GLUTAMIC OXALACETIC TRANSAMINASE.


Exposures to the picolines may give rise to flushing of the face, skin rash, an increase in heart and respiration rates, headache, giddiness, nausea and vomiting. /Picolines/


ALKYL DERIVATIVES, PICOLINES ... CAUSE SYMPTOMS RESEMBLING THOSE OBSERVED WITH PYRIDINE. THESE ARE LARGELY NONSPECIFIC & INCL WEAKNESS, ATAXIA, DIARRHEA, & UNCONSCIOUSNESS. DELAYED DEATHS FOLLOWING SINGLE DOSE ARE UNCOMMON & SURVIVORS GENERALLY GAIN WT NORMALLY. /PICOLINES/


Applicant's summary and conclusion

Conclusions:
CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF PYRIDINE INCLUDE WEIGHT LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS.