Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well conducted study similar to OECD 401 protocol. The study was done prior to implementation of GLPs.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
b-Picoline
IUPAC Name:
b-Picoline
Constituent 2
Chemical structure
Reference substance name:
3-methylpyridine
EC Number:
203-636-9
EC Name:
3-methylpyridine
Cas Number:
108-99-6
Molecular formula:
C6H7N
IUPAC Name:
3-methylpyridine

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
320, 630, 1,300, 2,000, 3,200, 5,000 mg/kg
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Clinical signs

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
630 mg/kg bw
Based on:
test mat.
Mortality:
320 mg/kg - 0/3
630 mg/kg - 1/3
1,300 mg/kg - 3/3
2,000 mg/kg - 3/3
3,200 mg/kg - 3/3
5,000 mg/kg - 3/3
Clinical signs:
320 mg/kg = lethargy and watery eyes
630, 1,300 and 2,000 mg/kg = lethargy, watery eyes, loss of motor coordination, excessive salivation, rapid shallow breathing and unconsciousness
3,200 mg/kg = watery eyes, excessive salivation, rapid shallow breathing and unconsciousness
5,000 mg/kg = rapid shallow breathing and unconsciousness

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information meets criteria of 300 mg/kg bw < LD50 < 2000 mg/kg bw. Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 of b-picoline in male Fisher rats was approximately 630 mg/kg. This meets the criteria for classification as Category 4 according to Regulation EC No. 1272/2008.