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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well-conducted study similar to OECD 402 protocol.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1983

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
b-Picoline
IUPAC Name:
b-Picoline
Constituent 2
Chemical structure
Reference substance name:
3-methylpyridine
EC Number:
203-636-9
EC Name:
3-methylpyridine
Cas Number:
108-99-6
Molecular formula:
C6H7N
IUPAC Name:
3-methylpyridine

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 Hours
Doses:
200, 800, 2000 mg/kg
No. of animals per sex per dose:
2/dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations - daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 800 - < 2 000 mg/kg bw
Based on:
test mat.
Mortality:
200 mg/kg -0/2
800 mg/kg - 0/2
2,000 mg/kg - 2/2
Clinical signs:
200 mg/kg - lethargy
800 mg/kg - lethargy, apparent loss of appetite and semi-consciousness
2,000 mg/kg - semi-consciousness, watery eyes and rapid shallow breathing

Body weight:
The majority of surviving rabbits gained weight during the two-week observation period.

Any other information on results incl. tables

Moderate redness, slight to moderate swelling and moderate necrosis were observed on the application sites of surviving rabbits 24 hours post exposure.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Meets criteria of 300 mg/kg bw < LD50 < 2000 mg/kg bw. Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 of b-picoline in rabbits was > 800 and < 2000 mg/kg bw. The substance is classified as Category 4 according to Regulation EC No. 1272/2008.