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EC number: 200-091-9 | CAS number: 51-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-07-13 to 2017-08-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- GLP compliance:
- no
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Thai Kyowa Biotechnologies Co. Ltd. / batch 160006
- Expiration date of the lot/batch: 2018-02-22
- Purity test date:2016-03-08
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Ambient temperature (15 °C - 25 °C), protected from light
- Stability under test conditions: stable
-
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: none - Key result
- Percentile:
- other: L50
- Mean:
- 274.1 µm
- Remarks on result:
- other: St. dev. not reported
- Percentile:
- other: L10
- Mean:
- 59.1 µm
- Remarks on result:
- other: St. dev. not reported
- Percentile:
- other: L90
- Mean:
- 663.8 µm
- Remarks on result:
- other: St. dev. not reported
- Conclusions:
- The median particle size L50 of the test item deduced from the particle size distributions was
274.1 µm.
The particle size L10 of the test item deduced from the particle size distributions was
59.1 µm.
The particle size L90 of the test item deduced from the particle size distributions was
663.8 µm. - Executive summary:
The particle size distribution of L-4-Hydroxyproline was determined by laser diffraction in a study according to OECD 110.
The median particle size L50 of the test item deduced from the particle size distributions was
274.1 µm.
The particle size L10 of the test item deduced from the particle size distributions was
59.1 µm.
The particle size L90 of the test item deduced from the particle size distributions was
663.8 µm.
Reference
Description of key information
The median particle size L50 of the test item deduced from the particle size distributions was
274.1 µm.
The particle size L10 of the test item deduced from the particle size distributions was
59.1 µm.
The particle size L90 of the test item deduced from the particle size distributions was
663.8 µm.
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