Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Eye irritation, Eye Irritection assay, H318: Causes serious eye damage
Skin irritation, Dermal Irritection assay, slight irritant. Overall assessment: not skin irritant

Key value for chemical safety assessment

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Additional information

In vitro Irritection tests are available for both eye and skin irritation properties (Ricci; 2002) on the substance and on a group of substances that differ from the target substance only for the lenght of the fatty acid in the final structure.

Eye irritation was determined by Ocular Irritection Assay on the substance (and similar substances) with a result as a mild/modearte eye irritant in the Draize score system.

Skin irritation was determined on the substance by Dermal Irritection Assay, which resulted as mild skin irritant. However, based on the considerations reported in the attached document and on the read across considerations no skin irritation potential is considered for the substance while eye irritation potential is classified as H318.



Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

The irritative scores determined by the Irritection Assay (dermal and Ocular) classify the substance as H318 and do not classify the substance for skin irritation under Regulation 1272/2008 ( refer to the attached document).

Categories Display