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Diss Factsheets
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EC number: 263-336-9 | CAS number: 61931-80-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication with limited details on methods, but study seems to be performed under standardized conditions.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attached justification
- Reason / purpose for cross-reference:
- read-across source
- Preliminary study:
- Not relevant
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 790 mg/kg bw
- 95% CL:
- 2 440 - 3 180
- Remarks on result:
- other: Slope function 1.3 (95% CI 1.2-1.4)
- Mortality:
- Death time 4-18 hr
- Clinical signs:
- Ataxia soon after treatment
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- Not relevant
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of Linalool for rats was found to be 2790 mg/kg bodyweight. Based on this LD50 value, the substance is not classified according to Regulation (EC) 1272/2008. This result was used for read-across to ethyllinalyl acetate.
- Executive summary:
The acute oral toxicity of Linalool to rats was investigated. 10 animals per concentration were used, the substance was administered orally via gavage. The LD50 was found to be 2790 mg/kg body weight. This result was used for read-across to ethyllinalyl acetate.
Not relevant
Data source
Reference
- Reference Type:
- publication
- Title:
- Food flavourings and compounds of related structure; I. Acute oral toxicity
- Author:
- Jenner PM, Hagan EC, Taylor JM, Cook EL and Fitzhugh OG
- Year:
- 1 964
- Bibliographic source:
- Food Cosmet. Toxicol. Vol. 2, pp. 327-343. Pergamon Press 1964.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-1,6-dien-3-ol
- Details on test material:
- A commercially available material was used.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: no data- Age at study initiation: young adults- Weight at study initiation: no data- Fasting period before study: 18 hours- Water (e.g. ad libitum): animals had access to water at all timesENVIRONMENTAL CONDITIONSNo data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: The usual observation period was 2 weeks; in a few cases, where no acute toxic signs were seen, the animals were observed for only one week.- Frequency of observations and weighing: Frequency not known, all animals were maintained under close observation for recording toxic signs and time of death. Such observation was continued until animals appeared normal or showed weight gain.
- Statistics:
- LD50's were computed by the method of Litchfield & Wilcoxon (1949).
Results and discussion
- Preliminary study:
- Not relevant
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 790 mg/kg bw
- 95% CL:
- 2 440 - 3 180
- Remarks on result:
- other: Slope function 1.3 (95% CI 1.2-1.4)
- Mortality:
- Death time 4-18 hr
- Clinical signs:
- Ataxia soon after treatment
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- Not relevant
Any other information on results incl. tables
Not relevant
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of Linalool for rats was found to be 2790 mg/kg bodyweight. Based on this LD50 value, the substance is not classified according to Regulation (EC) 1272/2008.
- Executive summary:
The acute oral toxicity of Linalool to rats was investigated. 10 animals per concentration were used, the substance was administered orally via gavage. The LD50 was found to be 2790 mg/kg body weight.
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