Registration Dossier
Registration Dossier
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EC number: 234-165-7 | CAS number: 10576-12-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of Acetohydroxamic acid (546-88-3) in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2017.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute Oral Toxicity Study of Acetohydroxamic acid (546-88-3) in Rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Acetohydroxamic acid
- EC Number:
- 208-913-8
- EC Name:
- Acetohydroxamic acid
- Cas Number:
- 546-88-3
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- Acetohydroxamic acid
- Details on test material:
- Name - Acetohydroxamic acid
InChI - 1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
Smiles - CC(=O)NO
- Molecular formula (if other than submission substance):C2H5NO2
- Molecular weight (if other than submission substance):75.0665 g/mole
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- Name - Acetohydroxamic acid
InChI - 1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
Smiles - CC(=O)NO
- Molecular formula (if other than submission substance):C2H5NO2
- Molecular weight (if other than submission substance):75.0665 g/mole
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 4800 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 800 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality observed at 4800 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 4800 mg/kg bw, when rats was treated with Acetohydroxamic acid (546-88-3) via oral route.
- Executive summary:
In an acute oral toxicity study, rats were treated with Acetohydroxamic acid (546-88-3) at the concentration of 4800mg/kg bworally. 50% mortality was observed in treated rats at 4800 mg/kg bw. Therefore, LD50 was considered to be 4800 mg/kg bw, when rats was treated with Acetohydroxamic acid via oral route.
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