Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 617-879-7 | CAS number: 865536-03-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 16.4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 230 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Conversion of an oral rat NOAEL into a corrected inhalatory NOAEC to assess human inhalatory exposure
Corretion factor diffrence in resperatory volumes: 2.63
Corretion factor light activity for workers: 0.67
Correction factor for bioavailability (oral-inhalation worst case): 0.5
Correction factor for difference in human and exposure of worker: 1.4
(ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for dose response relationship:
- 1
- Justification:
- Starting point is NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute (28 Days study) to chronic (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- allometric scalling during modification of the starting point (resperatory Volumes human/rat) (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for other interspecies differences:
- 2.5
- Justification:
- No substance -sepcific data for metabolic rate are available (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for intraspecies differences:
- 5
- Justification:
- Standard factor for workers (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for the quality of the whole database:
- 1
- Justification:
- good standard quality (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 400 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Correction factor for difference in human and exposure of worker: 1.4
- AF for dose response relationship:
- 1
- Justification:
- Starting point is NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute (28 Days study) to chronic (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard factor from rat to human (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for other interspecies differences:
- 2.5
- Justification:
- No substance -sepcific data for metabolic rate are available (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for intraspecies differences:
- 5
- Justification:
- Standard factor for workers (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for the quality of the whole database:
- 1
- Justification:
- good stadard quality (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.47 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Value:
- 370 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Conversion of an oral rat NOAEL into a corrected inhalatory NOAEC to assess human inhalatory exposure:
Corretion factor diffrence in resperatory volumes: 0.74
Correction factor for bioavailability (oral-inhalation worst case): 0.5
(ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for dose response relationship:
- 1
- Justification:
- Starting point is NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute (28 Days study) to chronic (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard factor from rat to human (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for other interspecies differences:
- 2.5
- Justification:
- No substance -sepcific data for metabolic rate are available (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for intraspecies differences:
- 10
- Justification:
- standard factor for difference in population (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for the quality of the whole database:
- 1
- Justification:
- good standard quality (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
no modifications
- AF for dose response relationship:
- 1
- Justification:
- NOAEL is starting point
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute (28 Days study) to chronic (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard factor from rat to human (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for other interspecies differences:
- 2.5
- Justification:
- No substance -sepcific data for metabolic rate are available (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for intraspecies differences:
- 10
- Justification:
- standard factor for difference in population (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for the quality of the whole database:
- 1
- Justification:
- good standard quality
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
no modifications
- AF for dose response relationship:
- 1
- Justification:
- NOAEL is starting point
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute (28 Days study) to chronic (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard factor from rat to human (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for other interspecies differences:
- 2.5
- Justification:
- No substance -sepcific data for metabolic rate are available (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for intraspecies differences:
- 10
- Justification:
- standard factor for difference in population (ECHA Guidance on informationrequiremnts and chemical safety assessment Chapter R.8)
- AF for the quality of the whole database:
- 1
- Justification:
- good standard quality
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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