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EC number: 617-879-7 | CAS number: 865536-03-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Version / remarks:
- SEPA chemical testing methods Editorial Board. The Guidelines for Testing of Chemicals (Health Effects part) [M]. China Environmental Science Press. 2013 : 258-276
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- other: infection method
- Limit test:
- yes
Test material
- Reference substance name:
- bis(11-methyldodecyl) ((((1,3-phenylenebis(methylene)bis(azanediyl))bis(carbonyl) bis(azanediyl))bis(4-methyl-3,1-phenylene) dicarbamate
- Cas Number:
- 865536-03-4
- Molecular formula:
- C52H80N6O6
- IUPAC Name:
- bis(11-methyldodecyl) ((((1,3-phenylenebis(methylene)bis(azanediyl))bis(carbonyl) bis(azanediyl))bis(4-methyl-3,1-phenylene) dicarbamate
- Reference substance name:
- bis(11-methyldodecyl)(4-methyl-1,3-phenylene)dicarbamate
- Molecular formula:
- C35H62N2O4
- IUPAC Name:
- bis(11-methyldodecyl)(4-methyl-1,3-phenylene)dicarbamate
- Reference substance name:
- 11-methyldodecyl (3-(3-(3-(aminomethyl)benzyl)ureido)-4-methylphenyl)carbamate
- Molecular formula:
- C30H46N4O3
- IUPAC Name:
- 11-methyldodecyl (3-(3-(3-(aminomethyl)benzyl)ureido)-4-methylphenyl)carbamate
- Reference substance name:
- 1,1'-(4-methyl-1,3-phenylene)bis(3-(3-(aminomethyl)benzyl)urea)
- Molecular formula:
- C25H30N6O2
- IUPAC Name:
- 1,1'-(4-methyl-1,3-phenylene)bis(3-(3-(aminomethyl)benzyl)urea)
- Test material form:
- solid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rats reared in stainless steel wire cages (500W x 350D x 200H mm), 5 animals were housed in a cage, every single gender in a cage Drinking water and feed were provided ad libitum. The animal rooms were cleaned once a day and autoclaved aluminum trays were replaced three times a week. During the test period, the animal room kept temperature at 21.9-23.5 'C, humidity in 51.9-59.6 %. Pressure between room and corridor was greater than 10 Pa, ventilation was more than 15 times per hour, and lighting period was 12 hours per day (8:00-20:00).
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- other: nose and mouth
- Vehicle:
- air
- Duration of exposure:
- ca. 4 h
- Concentrations:
- limit test at 5.0 mg/L
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- 10 rats (5 ♂ and 5 ♀) were employed in acute inhalation toxicity test. The test animals were weighed before exposure and placed in the container. Rats were infected at the dose of 5.0 mg/L after balancing test concentration for 4 hours.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No obvious toxicity and no death of test rats were showed during test, Observed and recorded during the test.
- Clinical signs:
- other: No obvious toxicity of test rats were observed during exposure.
- Body weight:
- Body weights of test rats increased significantly during the experimental period.
- Gross pathology:
- No obvious abnormalities of test rats induced by ADDUKT TI180-MXDA were observed by necropsy at the end of study period.
- Other findings:
- No obvious toxicity of test rats were observed during exposure.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance ADDUKT TI180-MXDA (batch number: #VPE 1724/18) inhalation infection at the dose of 5.0 mg/L for 4 hours observed no obvious toxicities. No obvious abnormalities of test rats induced by ADDUKT TI180-MXDA were observed by necropsy at the end of study period. The suction LC50 of test substance ADDUKT TI180-MXDA is greater than 5.0 mg/L. Under the present experimental conditions, rats were observed no obvious toxicities after infecting with the test substance ADDUKT TI180-MXDA (batch number: #VPE 1724/18) at the dose of 5.0 mg/L. The suction LC50 of ADDUKT TI180-MXDA is greater than 5.0 mg/L.
- Executive summary:
Purpose:
To evaluate the toxic effects and reversibility of ADDUKT TI180-MXDA by observing functional and morphological changes after inhalation administration of ADDUKT TI180-MXDA at dose of 5.0 mg/L to SD rats. This test will also provide information for both the acute toxicity classification and sub-chronic exposure doses.
Method:
10 rats (5♂and 5♀) were employed in acute inhalation toxicity test. The test animals were weighed before exposure and placed in the container. Rats were infected at the dose of 5.0 mg/L after balancing test concentration for 4 hours. Animals were daily observed for 14 days. All observations from individual rat were systematically recorded. Body weight of each animal was recorded prior to administration (recorded as d0), d1, d3, d7 and d14 respectively. All test animals should be subjected to gross necropsy. The observation of heart, lung, kidney, Iiver, spleen, gastrointestinal tract and other organs were performed to make sure whether there were any hemorrhage and edema.
Result:
No obvious toxicities were observed on test rats infected by ADDUKT TI180-MXDA at the dose of 5.0 mg/L. Body weights increased significantly during the experimental period. No obvious abnormalities of test rats induced by ADDUKT
TI180-MXDA were observed by necropsy at the end of study period.
Conclusion:
Under the present experimental conditions, rats were observed no obvious toxicities after infecting with the test substance ADDUKT TI180-MXDA (batch number: #VPE 1724/18) at the dose of 5.0 mg/L. The suction LC50of ADDUKT TI180-MXDA is greater than 5.0 mg/L.
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