Registration Dossier
Registration Dossier
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EC number: 215-885-0 | CAS number: 1443-80-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study of Benzonitrile (100-47-0) in rat
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- IFA GESTIS, GESTIS SUBSTANCE Database, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study for Benzonitrile (100-47-0) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Benzonitrile
- EC Number:
- 202-855-7
- EC Name:
- Benzonitrile
- Cas Number:
- 100-47-0
- Molecular formula:
- C7H5N
- IUPAC Name:
- Benzonitrile
- Details on test material:
- Name - Benzonitrile
InChI - 1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H
Smiles - c1(ccccc1)C#N
- Molecular formula (if other than submission substance):C7H5N
- Molecular weight (if other than submission substance):103.123 g/mole
- Substance type:Organic
- Physical state:Liquid – colourless
Constituent 1
- Specific details on test material used for the study:
- Name - Benzonitrile
InChI - 1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H
Smiles - c1(ccccc1)C#N
- Molecular formula (if other than submission substance):C7H5N
- Molecular weight (if other than submission substance):103.123 g/mole
- Substance type:Organic
- Physical state:Liquid – colourless
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- not specified
- Concentrations:
- 38600 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Other examinations performed: Animals were observed for clinical signs.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 38 600 mg/m³ air
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 38600 mg/m3
- Clinical signs:
- other: Rats showed the symptoms like: difficulty in breathing, ataxia, exhaustion, sedation and narcosis.
- Body weight:
- not specified
- Gross pathology:
- No substance-related macroscopic changes to organs were observed.
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute inhalation toxicity study in rat by using Benzonitrile (100-47-0) was considered to be 38600 mg/m3.
- Executive summary:
The acute inhalation toxicity study was conducted by using Benzonitrile (100-47-0) in rat at the concentration of38600 mg/m3. 50% mortality was observed at38600 mg/m3.Rats showed the symptoms like: difficulty in breathing, ataxia, exhaustion, sedation and narcosis. No substance-related macroscopic changes to organs were observed.Therefore, LC50 was considered to be38600 mg/m3when rat was treated with Benzonitrile by inhalation.
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