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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: p-methylacetophenone
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 933

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute Dermal Toxicity Study of 4'-methylacetophenone in Rabbits
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4'-methylacetophenone
EC Number:
204-514-8
EC Name:
4'-methylacetophenone
Cas Number:
122-00-9
Molecular formula:
C9H10O
IUPAC Name:
1-(4-methylphenyl)ethan-1-one
Details on test material:
Name - 4'-methylacetophenone
InChI - 1S/C9H10O/c1-7-3-5-9(6-4-7)8(2)10/h3-6H,1-2H3
Smiles - c1(C(C)=O)ccc(C)cc1
- Molecular formula (if other than submission substance):C9H10O
- Molecular weight (if other than submission substance):134.177 g/mole
- Substance type:Organic
Specific details on test material used for the study:
Name - 4'-methylacetophenone
InChI - 1S/C9H10O/c1-7-3-5-9(6-4-7)8(2)10/h3-6H,1-2H3
Smiles - c1(C(C)=O)ccc(C)cc1
- Molecular formula (if other than submission substance):C9H10O
- Molecular weight (if other than submission substance):134.177 g/mole
- Substance type:Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality observed at 2000 mg/kg bw
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be >2000 mg/kg bw, when rabbits were treated with 4'-Methylacetophenone (122-00-9) by dermal application.
Executive summary:

In an acute dermal toxicity study,rabbits were treated with 4'-Methylacetophenone (122-00-9) at the concentration of 2000mg/kg bw. No mortality was observed at 2000 mg/kg bw. Therefore,LD50 was considered to be >2000 mg/kg bw, whenrabbits were treated with 4'-Methylacetophenone by dermal application.

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