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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authoritive database

Data source

Reference
Reference Type:
review article or handbook
Title:
Skin irritation for CAS NO: 119-61-9
Author:
IFA (GESTIS)
Year:
2017
Bibliographic source:
GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation study of Benzophenone was conducted in rabbits to assess the irritation potential
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzophenone
EC Number:
204-337-6
EC Name:
Benzophenone
Cas Number:
119-61-9
Molecular formula:
C13H10O
IUPAC Name:
Benzophenone
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): Benzophenone
- Molecular formula: C13H10O
- Molecular weight: 182.22 g/mol
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Benzophenone
- Molecular formula: C13H10O
- Molecular weight: 182.22 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
0.1mL
Duration of treatment / exposure:
No Data Available
Observation period (in vivo):
No Data Available
Duration of post- treatment incubation (in vitro):
No Data Available
Number of animals or in vitro replicates:
No Data Available
Details on study design:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation was observed.
Other effects:
No Data Available

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test material Benzophenone (CAS No: - 119-61-9) was considered to be not irritating to rabbits’ eye.
Executive summary:

An eye irritation study of Benzophenone (CAS No: -119-61-9)was performed in rabbits to assess its effects in rabbits’ eye.

The test substance was placed in rabbit’s eye at volume of 0.1ml and observed for any ocular changes.

Since the chemical did not induce any adverse effects, Benzophenone (CAS No: -119-61-9)was considered to be not irritating to rabbits’ eye.