Sodium metaphosphate

Endpoint summary

Key value for chemical safety assessment

Effects on fertility

Description of key information

Supporting study:

Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate.

Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.

Link to relevant study records

Reference

Endpoint:

three-generation reproductive toxicity

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Justification for type of information:

A scientific review.

Principles of method if other than guideline:

Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate. Two litters per generation were examined.

GLP compliance:

not specified

Species:

rat

Strain:

not specified

Route of administration:

oral: feed

Details on exposure:

Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate or 0.05% Sodium
Trimetaphosphate. Two litters per generation were examined.

Details on mating procedure:

The rats (16 females and 8males per group) were mated when the rats were each 100 days old.

Diet containing 0.05% Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.

Conclusions:

Diet containing 0.05% Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.

Executive summary:

Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate.

Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.

Effects on developmental toxicity

Description of key information

Supporting study:

Wistar rats were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant rats a given up to 240 mg/kg/day  respectively, no effects on nidation, maternal survival, or fetal survival were observed.

The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.

Supporting study:

CD-1 mice e were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant a given up to 370 mg/kg/day  respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.

Link to relevant study records

Reference

Reference 1

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Justification for type of information:

A scientific review.

Principles of method if other than guideline:

Pregnant Wistar rats were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation.

GLP compliance:

not specified

Species:

rat

Strain:

Wistar

Route of administration:

oral: gavage

For pregnant rats given up to 240 mg/kg/day no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.

Conclusions:

For pregnant rats a given up to 240 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.

Executive summary:

Wistar rats were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant rats a given up to 240 mg/kg/day  respectively, no effects on nidation, maternal survival, or fetal survival were observed.

The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.

Reference 2

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Justification for type of information:

A scientific review.

Principles of method if other than guideline:

Pregnant CD-1 mice were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation.

GLP compliance:

not specified

Species:

rat

Strain:

Wistar

Route of administration:

oral: gavage

For pregnant mice given up to 370 mg/kg/day no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.

Conclusions:

For pregnant mice a given up to 370 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.

Executive summary:

CD-1 mice e were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant a given up to 370 mg/kg/day  respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.