Registration Dossier
Registration Dossier
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EC number: 605-738-2 | CAS number: 174863-37-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-amino-N-(4-amino-6-oxo-5H-pyrimidin-2-yl)benzenesulfonamide
- EC Number:
- 605-738-2
- Cas Number:
- 174863-37-7
- Molecular formula:
- C10H11N5O3S
- IUPAC Name:
- 4-amino-N-(4-amino-6-oxo-5H-pyrimidin-2-yl)benzenesulfonamide
- Test material form:
- other:
- Remarks:
- paste
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 1
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 1
- Irritant / corrosive response data:
- In the course of the first hour after administration, the substance induced vessels clearly more injected than normal (grade 1) in the palpebral conjunctivae of all animals, accompanied by some swelling above normal of the lids (grade 1) and slight discharge.
All the animals showed injected vessels in the bulbar conjunctivae.
24, 48 and 72 hours after administration, the eye injuries seen in the previous readings had totally subsided at which point the observation period ended.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material is considered as non-irritant to the rabbit eye
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