3-isopropoxypropylamine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16. Sep 1969 - 19. Sep 1969

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Principles of method if other than guideline:

Fifty µL of 3-isopropoxypropylamine were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isopropoxypropylamine

IUPAC Name:

Isopropoxypropylamine

Details on test material:

- Name of test material (as cited in study report): Isopropoxy-propylamin
- Analytical purity: > 99 %

Test animals / tissue source

Species:

rabbit

Strain:

Vienna White

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 3.08 and 3.11 kg

Test system

Vehicle:

unchanged (no vehicle)

Controls:

other: The adjacent eye served as control treated with 0.9 % NaCl (saline).

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µl

Duration of treatment / exposure:

Single application

Observation period (in vivo):

Animals were sacrificed ahead of schedule

Number of animals or in vitro replicates:

2

Results and discussion

In vivo

Results

Irritation parameter:

other: corrosion

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

3

Max. score:

3

Reversibility:

not reversible

Any other information on results incl. tables

The application of the test substance caused corrosion to the exposed eyes and therefor a precise evaluation of opacity, erythema, chemosis and iritis was not possible. Major finding: irreversible corrosion of the eyes.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye)

Remarks:

Migrated information Criteria used for interpretation of results: EU

Executive summary:

Fifty µL of 3-isopropoxypropylamine were applied to the conjunctival sac of one eye in 2 animals (BASF, 1970d). The animals were observed after 10 min, 1 and 3h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours. The report describes findings after 1 and 24 hours and at the end of the observation period. For final evaluation, the findings after 48 and 72 hours from the raw data were taken into account. The application of 3-isopropoxypropylamine caused corrosion to the exposed eyes and therefore a precise evaluation of opacity, erythema, chemosis and iritis was not possible.