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EC number: 701-197-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert statement
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An extensive Assessment of the toxicological behaviour of 1,2,3-Propanetriol, glycidyl ethers was performed, taking into account the chemical structure, the available physico-chemical-data and the available (eco-)toxicological data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An extensive Assessment of the toxicological behaviour of 1,2,3-Propanetriol, glycidyl ethers was performed, taking into account the chemical structure, the available physico-chemical-data and the available (eco-)toxicological data.
Test material
- Reference substance name:
- Reaction products of 2-(chloromethyl)oxirane and glycerol
- EC Number:
- 701-197-2
- Molecular formula:
- 6 individual glycidether components (Molecular range ca. 200 - 600 g/mol)
- IUPAC Name:
- Reaction products of 2-(chloromethyl)oxirane and glycerol
- Details on test material:
- not applicable
Constituent 1
- Radiolabelling:
- other: not applicable in this expert statement
Test animals
- Species:
- other: not applicable
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: all routes of administration are discussed in the expert statement
- Vehicle:
- other: not applicable
- Details on exposure:
- all routes of administration are discussed in the expert statement
- Details on study design:
- not applicable
- Details on dosing and sampling:
- not applicable
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- The absorption into the body is assumed not to be favoured due to the absorption-hindering properties (high water solubility (1000 g/L) and a negative logPow ( -1.78 /-1.94) and the observed effects in toxicological studies.
- Type:
- distribution
- Results:
- The distribution is expected to be limited, reaching only the intravasal compartment, due to a negative logPow (-1.78/-1.94).
- Type:
- metabolism
- Results:
- Epoxyde hydrolases presented in mammalian species, reduce glycidyl ethers to their corresponding diols. They can be further oxidised or conjugated with glutathione.
- Type:
- excretion
- Results:
- The parent substance is expected to be excreted unchanged and/or metabolised via the urine.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The absorption into the body of 1,2,3-propanetriol, glycidyl ethers is assumed not to be favoured due to the absorption-hindering properties (high water solubility (1000 g/L) and a negative logPow ( -1.78 /-1.94) and the observed effects in toxicological experiments. Absorption by oral route is expected to be moderate. The substance has a very low/low vapour pressure, which indicates only marginal availability for inhalation and inhaled substance is expected not to be absorbed. Dermal absorption is expected to be low.
- Details on distribution in tissues:
- In case of 1,2,3-propanetriol, glycidyl ethers, no data is available for distribution patterns. The distribution is expected to be limited, reaching only the intravasal compartment, due to its better solubility in water than in octanol (logPow -1.78/-1.94).
- Details on excretion:
- For 1,2,3-propanetriol, glycidyl ethers no data is available concerning its elimination. Concerning the above mentioned behaviour predicted for its metabolic fate, its chemicals structure and its molecular weight, it is very likely that the parent substance will be excreted unchanged and metabolised via the urine.
Applicant's summary and conclusion
- Conclusions:
- An extensive assessment of the toxicological behaviour of 1,2,3-propanetriol, glycidyl ethers was performed (expert statement), taking into account the chemical structure, the available physico-chemical-data and the available (eco-)toxicological data.
- Executive summary:
In order to assess the toxicological behaviour of 1,2,3-propanetriol, glycidyl ethers, the available physico-chemical and toxicological data have been evaluated. The substance is expected to be well absorbed after oral exposure, based on its water solubility, its logPow of -1.78 / -1.94 and acute toxicity data via oral administration. Concerning the absorption after exposure via inhalation, as the chemical has low vapour pressure and is highly hydrophilic, it is clear, that the substance is poorly available for inhalation and will not be absorbed significantly.1,2,3-propanetriol, glycidyl ethersis also not expected to be absorbed following dermal exposure into the stratum corneum and into the epidermis, due to its molecular weight and its logPow. Concerning its distribution in the body1,2,3-propanetriol, glycidyl ethersis expected to be distributed mainly in the intravasal compartment, due to its logPow. The substance does not indicate a significant potential for accumulation.1,2,3-propanetriol, glycidyl ethersis expected to be metabolised mainly via epoxide hydrolases (esterases), cytochrome P450s and alcohol dehydrogenase and subsequently eliminated unchanged or as metabolites via the urine.
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