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EC number: 701-197-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented publication, which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicology of Epoxy Resins
- Author:
- Hine, C.H., Kodama, J.K., Anderson, H.H., Simonson, D.W., Wellington, J.S.
- Year:
- 1 958
- Bibliographic source:
- AMA archive s of industrial health / American Medical Association, 17, p. 129-144
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of 10 male rats (80-104 gm.) were exposed five days a week for seven hours, for a total of 50 exposures, to air saturated with the vapor of EPON 562. Similarly, a group of 10 control rats were exposed to uncontaminated air. The animals were exposed in cylindrical steel chambers of 210-liter capacity at 20±1°C. The rats were observed for signs of intoxication during and after each exposure. Individual weights were recorded weekly. At the end of the experimental period, the rats were killed and examined for gross changes. Representative tissues were taken for histologic study, and the organ/body weight ratios were determined on liver, lungs, and kidneys for statistical analysis.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Polyglycidyl Ether of Substituted Glycerin (EPON 562)
- IUPAC Name:
- Polyglycidyl Ether of Substituted Glycerin (EPON 562)
- Details on test material:
- - Name of test material (as cited in study report): EPON 562
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 80 - 104 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Remarks:
- The animals were exposed in cylindrical steel chambers of 210-liter capacity at 20±1°C.
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: cylindrical steel chambers of 210-liter capacity at 20±1°C.
- Method of holding animals in test chamber: free in chamber
- Temperature, humidity, pressure in air chamber: 20±1°C.
- Air flow rate: 15 L/min
TEST ATMOSPHERE
- Brief description of analytical method used: none
- Samples taken from breathing zone: no
Other:
Air was substantially saturated with EPON 562 by passage through two fritted glass bubblers connected in series. The airflow rate was held constant at 15 liters per minute. A preliminary saturation period of about an hour insured greater than 95% saturation of the air prior to the exposure of animals. No analytical check was made of the concentration, since it was too low to permit accuracy of determination in either case. - Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- not applicable
- Duration of treatment / exposure:
- seven hours
- Frequency of treatment:
- 5 days / week ( for 50 exposures)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
air saturated with the vapour of EPON 562
Basis:
no data
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
Examinations
- Observations and examinations performed and frequency:
- The rats were observed for signs of intoxication during and after each exposure. Individual weights were recorded weekly, and mean weight changes were graphed in the form of growth curves.
- Sacrifice and pathology:
- At the end of the experimental period, the rats were decapitated under light ether anesthesia, exsanguinated, and examined for gross changes. Representative tissues were taken for histologic study, and the organ/body weight ratios were determined on liver, lungs, and kidneys for statistical analysis.
- Other examinations:
- no other examinations reported
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Aside from a very slight incrustation of the eyelids of some animals, with red-brown exudate, no rat showed any signs of toxicity or irritation attributable to the exposure. 1 rat of the DGR group & 2 in the .control group died between the 3. & 4.th week.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- Aside from a very slight incrustation of the eyelids of some animals, with red-brown exudate, no rat showed any signs of toxicity or irritation attributable to the exposure. 1 rat of the DGR group & 2 in the .control group died between the 3. & 4.th week.
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- Analysis of variance showed no significant difference in mean weight gains or in organ/body weight ratios (P = < 0.05).
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- At necropsy of the animals that died during the exposure period, bronchopneumonia was found. No significant gross or microscopic lesions were found in the surviving animals.
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- other: saturated vapour
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: No clinical signs, very slight incrustation of the eyelids; no significant gross or microscopic lesions.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEC identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The series of 50 exposures to the saturated vapors of EPON 562 and DGR was singularly free of untoward effects. Aside from a very slight incrustation of the eyelids of some animals, with red-brown exudate, none of the rats showed any signs of toxicity or irritation attributable to the exposure. One rat of the DGR group and two in the .control group died between the third and fourths weeks. At necropsy of these animals, bronchopneumonia was found. No significant gross or microscopic lesions were found in the surviving animals. Analysis of variance showed no significant difference in mean weight gains or in organ/body weight ratios (P = < 0.05).
Applicant's summary and conclusion
- Conclusions:
- The study was considered to be of high reliability (reliability Klimisch 2), because of the detailed documentation of the methods used and the results obtained. The test material, EPON 562 did not induce mortality and treatment-related clinical signs in treated rats. No practical or systemic toxicity hazard could be associated with exposure to the vapors of the resin.
- Executive summary:
The repeated toxicity of the read-across substance polyglycidyl ether of substituted glycerine (EPON 562) was investigated by Hine et al. (1958). The effect of inhalation of the EPON 562 was tested on rats (male Long Evans). Groups of 10 male rats were exposed five days a week for seven hours, for a total of 50 exposures, to air saturated with the vapour of EPON 562. Similarly, a group of 10 control rats was exposed to uncontaminated air. The animals were exposed in cylindrical steel chambers of 210-liter capacity at 20±1C. Air was substantially saturated with EPON 562 by passage through two fritted glass bubblers connected in series. The airflow rate was held constant at 15 liters per minute. A preliminary saturation period of about an hour insured greater than 95% saturation of the air prior to the exposure of animals. No analytical check was made of the concentration, since it was too low to permit accuracy of determination in either case. The rats were observed for signs of intoxication during and after each exposure. Individual weights were recorded weekly, and mean weight changes were graphed in the form of growth curves. At the end of the experimental period, the rats were decapitated under light ether anesthesia, exsanguinated, and examined for gross changes. Representative tissues were taken for histologic study, and the organ/body weight ratios were determined on liver, lungs, and kidneys for statistical analysis. The series of 50 exposures to the saturated vapors of EPON 562 was singularly free of untoward effects. Aside from a very slight incrustation of the eyelids of some animals, with red-brown exudate, none of the rats showed any signs of toxicity or irritation attributable to the exposure. Two rats in the control group died between the third and fourth weeks. At necropsy of these animals, bronchopneumonia was found. No significant gross or microscopic lesions were found in the surviving animals. Analysis of variance showed no significant difference in mean weight gains or in organ/body weight ratios (P≤0.05).
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