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EC number: 701-197-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD Toolbox 3.1, is a harmonized system for OSAR application and grouping chemicals into categories, which OECD principles are met.
Data source
Reference
- Reference Type:
- other: prediction by the OECD QSAR Toolbox
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Principles of method if other than guideline:
- Category members were tested according to the different guidelines
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2,3-epoxypropan-1-ol
- EC Number:
- 209-128-3
- EC Name:
- 2,3-epoxypropan-1-ol
- Cas Number:
- 556-52-5
- Molecular formula:
- C3H6O2
- IUPAC Name:
- oxiran-2-ylmethanol
- Details on test material:
- Target substance:
Mixture of 1,2,3-Propanetriol, polymer with 2-(chloromethyl)oxirane (CAS 25038-044-4) and 1,2,3-Propanetriol, glycidyl ethers:
SMILES:C(O)(CO)CO_C1(CCl)CO1_C1(COC(COCC2CO2)COCC2CO2)CO1
Read-across substances are lited in the Toolbox generated report
Constituent 1
Test animals
- Species:
- other: Mouse;Rat
Administration / exposure
- Route of administration:
- other: "MM B6C3F1, Gavage (TB:Neg);";"RM Lewis, IP (TB:ND);";"MM B6C3F1, IP (TB:Pos);";"MM B6C3F1, IP (TB:PosHD);";"RM SPRAGUE-DAWLEY, IP (TB:ND);";"MM BALB/C, IP Reticulocytes (TB:ND);";"MM (102XC3H)F1, IP (TB:ND); RM LEWIS, IP (TB:ND);"
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- positive
- Toxicity:
- not specified
- Remarks on result:
- other: see "any other information on results incl. tables"
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: "Chromosome aberration"
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain logical expression: Result: In Domain
(("a" and ("b" and ( not "c") ) ) and ("d" and "e" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Epoxides by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Alcohol AND Alkyl halide AND Dihydroxyl group AND Epoxide AND Ether AND Glycerol and derivatives AND Saturated heterocyclic fragment by Organic functional groups
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Alkane, branched with tertiary carbon OR Alkene OR Allyl OR Aryl OR Carboxamide OR Carboxylic acid OR Carboxylic acid ester OR Conjugated system OR Cycloalkane OR Fused saturated heterocycles by Organic functional groups
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.09
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.628
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): positive
The target chemical possesses three epoxide rings at the terminal position which are likely high reactive and can react with DNA molecule, inducing mutations etc. Based on the fact that most of the epoxy compounds (especially low molecular weight chemicals) are mutagenic or clastogenic in genetic toxicity tests, the target substance is considered to have genetic toxicity potential too. - Executive summary:
The target chemical was profiled as "Epoxides" by the "US EPA New Chemical Categories". Common properties of epoxides are high reactivity, cytotoxicity, and high probability of mutagenic potential and/or carcinogenicity. Therefore chemicals with the same profiling result have been retrieved from the database. The chemicals containing other chemical elements in their structure and/or other organic functional groups were considered dissimilar to the target chemical and have been removed from the domain. The target chemical is obtained by the reaction of epychlorohydrin with glycerol. Therefore, epichlorohydrin is considered to be a suitable candidate for read-across. Glycidol is the simplest representative of glycidyl ethers category (HPV, Epoxy Resin Systems Task Group (ERSTG), 2001). The other category members possess epoxy moieties in their structures and their profiling results regarding the ability to bind to proteins and to DNA (property which is likely responsible for genetic toxicity) are similar to those of the target chemical. Therefore, they considered to be suitable for read-across. The target substance was predicted to be positive in in vivo Micronucleus Test.
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