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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
Toxicology of the Eye. 2nd Edition
Author:
Grant
Year:
1974
Bibliographic source:
Charles C. Thomas, Springfield Illinois, 1974, p. 859

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Propiolactone
EC Number:
200-340-1
EC Name:
Propiolactone
Cas Number:
57-57-8
Molecular formula:
C3H4O2
IUPAC Name:
oxetan-2-one

Results and discussion

In vivo

Results
Irritation parameter:
other: Skin burning
Time point:
other: 20 min
Score:
ca. 100
Irritant / corrosive response data:
Human skin burns from contact for twenty minutes with 40% solution of propiolactone in water

Applicant's summary and conclusion