Registration Dossier
Registration Dossier
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EC number: 616-079-5 | CAS number: 74336-55-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methyl-1H,9H-pyrazolo[3,2-b]quinazolin-9-one
- EC Number:
- 616-079-5
- Cas Number:
- 74336-55-3
- Molecular formula:
- C11 H9 N3 O
- IUPAC Name:
- 2-methyl-1H,9H-pyrazolo[3,2-b]quinazolin-9-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, D-6050 Offenbach/Main, GER
- Age at study initiation: not specified
- Weight at study initiation: 2.92kg, 3.33 kg and 3.32 kg
- Housing: One animal per cage (type: stainless steel with wire mesh walk floors; floor area: 40 x 51 cm).
- Diet: Ovator Solikanin 4 mm; Muskator-Werke, D-4000 DUsseldorf-1 , GER (about 130 g per animal per day)
- Water: About 250 ml per animal per day: demineralized water (Monday-Friday), tap water (Saturday/Sunday)
- Acclimation period: at least 8 days before study start
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26
- Humidity (%): 30 - 70
- Air changes (per hr): 15 - 20 times/h
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 0.5 g of an 50% aqueous test substance preparation
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Upper third of the back or flank, application area: 2.5 x 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): At the end of the exposure period with Lutrol and Lutrol/water (1 : 1)
- Time after start of exposure:
SCORING SYSTEM: Draize System
Readings: 30 - 60 min after application start as well as 24, 48 and 72 h after removal of the test patches
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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