Registration Dossier
Registration Dossier
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EC number: 219-660-8 | CAS number: 2492-26-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- other: in vivo eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium benzothiazol-2-yl sulphide
- EC Number:
- 219-660-8
- EC Name:
- Sodium benzothiazol-2-yl sulphide
- Cas Number:
- 2492-26-4
- Molecular formula:
- C7H4NS2.Na
- IUPAC Name:
- sodium 2-sulfanylidene-2,3-dihydro-1,3-benzothiazol-3-ide
- Details on test material:
- merkaptobenzthiazol-Na (50%)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- white New Zealand, weight 3 to 4 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- amount: 100 µl
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2 per dose
- Details on study design:
- no further data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: highly irritating, corrosive to cornea
- Remarks on result:
- other: highly irritating, corrosive to cornea
- Irritant / corrosive response data:
- strong irritant
- Other effects:
- corrosive to the cornea
Any other information on results incl. tables
highly irritating
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Executive summary:
method: 2 animals received a dose of 100 µl/animal in the conjunctival sac, postexposure period 7 days.
result: strong irritant. corrosive to the cornea
reference: Thyssen/Bayer AG (1978)
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