Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
other: in vivo eye irritation study
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium benzothiazol-2-yl sulphide
EC Number:
219-660-8
EC Name:
Sodium benzothiazol-2-yl sulphide
Cas Number:
2492-26-4
Molecular formula:
C7H4NS2.Na
IUPAC Name:
sodium 2-sulfanylidene-2,3-dihydro-1,3-benzothiazol-3-ide
Details on test material:
merkaptobenzthiazol-Na (50%)

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
white New Zealand, weight 3 to 4 kg

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
amount: 100 µl
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2 per dose
Details on study design:
no further data

Results and discussion

In vivo

Results
Irritation parameter:
other: highly irritating, corrosive to cornea
Remarks on result:
other: highly irritating, corrosive to cornea
Irritant / corrosive response data:
strong irritant
Other effects:
corrosive to the cornea

Any other information on results incl. tables

highly irritating

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

method: 2 animals received a dose of 100 µl/animal in the conjunctival sac, postexposure period 7 days.

result: strong irritant. corrosive to the cornea

reference: Thyssen/Bayer AG (1978)