Registration Dossier
Registration Dossier
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EC number: 944-280-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates (daphnia)
EC 50 (48 h)= 0.17 ppm (measured)
Toxicity to aquatic algae and cyanobacteria (algae)
ErC50 (72 h) > 0.01 mg/l (calculated from the raw data)
Additional information
The following data was obtained for the Similar Substance 01. It is expected that the Target substance will present similar effect levels to daphnia and algae. Justification for Read Across is given in Section 13 of IUCLID.
Short-term toxicity to aquatic invertebrates (daphnia)
EC 50 (48 h)= 0.17 ppm (measured)
Toxicity to aquatic algae and cyanobacteria (algae)
EbC50 (72 h) = 0.0077 mg/l
NOEbC (72 h) = 0.0033 mg/l
ErC50 (72 h) > 0.01 mg/l (calculated from the raw data); available data on another Similar Substance suggests that the ErC50 (72h) is equal to 0.03 mg/l
The substance is non-readily biodegradable, is very water soluble and therefore bioavailable to the aquatic organisms. Its LogKow (<4) could suggest that the substance does not present a real potential to bioconcentrate. Comparing the results obtained for daphnia and algae, it seems that the most sensitive aquatic organism would be algae.
Justification for classification or non-classification
The classification of the substance for the aquatic toxicity was evaluated based on available data on Similar Substance 01.
Classification for acute aquatic toxicity is based on the following acute data:
EC 50 (48 h) Daphnia = 0.17 ppm (measured)
ErC50 (72 h) Algae > 0.01 mg/l (= 0.03 mg/l)
Based on the aquatic toxicity data the classification for Acute Category 1 (H400) is suggested.
For classification for chronic aquatic toxicity adequate chronic data for the 3 throphic levels is not available, therefore the main assessment is performed based on acute aquatic toxicity data and environmental fate data (biodegradation), according to CLP, Annex I, fig. 4.1.1, and table 4.1.0 (b)(iii). An EC50 < 1 mg/l for both daphnia and algae are obtained and the substance is non-readily biodegradable. Therefore, the classification for Chronic Category 1 (H410) is proposed.
An M-factor of 10 applies for acute toxicity and chronic toxicity.
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