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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
Not specified but between 13 March and 31 May 1961
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines
Justification for type of information:
Read across is based on the category approach. Please refer to attached category document.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1961
Report date:
1961

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Test material was administered via oral gavage to rats and the animals were observed for at least 14 days. Gross pathological examination was conducted on representative animals.
GLP compliance:
no
Test type:
other: Range finding study
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,6,9-trioxaundecane-1,11-diol
EC Number:
203-989-9
EC Name:
3,6,9-trioxaundecane-1,11-diol
Cas Number:
112-60-7
Molecular formula:
C8H18O5
IUPAC Name:
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
Constituent 2
Reference substance name:
Polyol PS
IUPAC Name:
Polyol PS
Test material form:
other: liquid, pale yellow
Details on test material:
Polyol PS (tetraethylene glycol with 200 APHA maximum)

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Remarks:
20% aqueous solution
Doses:
1.0, 2.0 and 3.98 g/kg
No. of animals per sex per dose:
2 rats/dose level
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 980 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

There were no deaths noted in rats at doses as high as 3980 mg/kg. Upon gross examination, very slight liver and kidney injury was noted at 3980 mg/kg, very slight liver injury was noted at 2000 mg/kg and no gross pathological effects were noted at 1000 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The test material has a low acute oral toxicity.
Executive summary:

The acute oral toxicity of tetraethylene glycol was examined. The acute oral LD50 is > 3980 mg/kg.