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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
Saturated perfluorocarbons have very similar toxicological properties and so a "read across" approach is justified.
Note that this is old data from testing done in 1995.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Perflunafene
EC Number:
206-192-4
EC Name:
Perflunafene
Cas Number:
306-94-5
Molecular formula:
C10F18
IUPAC Name:
1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-Octadecafluoronaphthalene
Test material form:
other: liquid
Details on test material:
F2 Chemicals internal identifier: L40092

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
4 hours
Observation period:
72 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 hr
Score:
ca. 0
Max. score:
0
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 72 hr
Score:
ca. 0
Max. score:
0
Irritant / corrosive response data:
"There were no apparent signs of irritation at the treated skin site on any animal throughout the 72 hour observation period.
The primary irritation index was calculated to be 0.0."

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
"Under the conditions of this study article, the test article, FLUTEC PC6, is considered to be non irritant to the skin of the albino rabbit."
Executive summary:

"Under the conditions of this study article, the test article, FLUTEC PC6, is considered to be non irritant to the skin of the albino rabbit."