Registration Dossier

Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
other: clinical observations and experimental results
Adequacy of study:
supporting study
Study period:
1988
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no information about GLP compliance of the published study.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1988

Materials and methods

Study type:
human medical data
Remarks:
obtained from clinical and experimental studies carried out in the employees
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline required
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Diallyl 2,2'-oxydiethyl dicarbonate
EC Number:
205-528-7
EC Name:
Diallyl 2,2'-oxydiethyl dicarbonate
Cas Number:
142-22-3
Molecular formula:
C12H18O7
IUPAC Name:
3-({[2-(2-{[(prop-2-en-1-yloxy)carbonyl]oxy}ethoxy)ethoxy]carbonyl}oxy)prop-1-ene
Details on test material:
Gas chromatographic and HPLC analysis of the DAGC revealed minor contamination with acrolein (18 ppm) and allyl alcohol (28 ppm).

Method

Type of population:
other: workers
Ethical approval:
not specified
Details on study design:
Patch Test

Results and discussion

Results:
Of the 7 operatives patch tested, 1 developed an allergic reaction to nickel sulphate 5% pet. and gave a previous history of nickel sensitivity. Patch tests were otherwise negative apart from minor irritant reactions to the diallyl glycol carbonate (DAGC) plus 3% isopropyl percarbonate (IPP) mixture at 0.1%. Similar irritant reactions to this mixture were seen in 5 control subjects.

Applicant's summary and conclusion

Conclusions:
In all patients, the eruptions all appear to have been irritant rather than allergic in origin.
Executive summary:

"We report an outbreak of irritant contact dermatitis from diallylglycol carbonate monomer among factory employees making optical plastic lenses. Symptoms lessened after simple preventive methods were introduced. Further upgrading of production methods lessened symptoms still further."