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Administrative data

Description of key information

Acute toxicity: oral: Wil Research Laboratories, Inc. Acute Oral Toxicity Study in Albino Rats with CR-39 (479-768) (1981); GLP; comparable to the OECD guideline 401.
Acute toxicity: dermal: Wil Research Laboratories, Inc. Acute Dermal Toxicity Study in Albino Rabbits with CR-39 (1981); comparable to the OECD guideline 402.
Acute toxicity: inhalation: Industrial BIO-TEST Laboratories, Inc. Acute vapor inhalation toxicity study with CR-39, 62310-31-151-1006 in albino rats (1971); comparable to the OECD guideline 403.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
515 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.
Value:
730 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
11 430 mg/kg bw

Additional information

Acute oral toxicity of carbonic acid, oxydiethylene diallyl ester to rats is moderate. The study " Acute Oral Toxicity Study in Albino Rats with CR-39 (479-768)" (dated 1981 -10 -22) was chosen as the key study for acute oral toxicity assessment because of its GLP compliance, a clear dose dependent responce (four dose levels tested) and LD50 which was calculated for both sexes.

Acute dermal toxicity to rabbits is low. When CR-39 was administered dermally at one dose level of 10 mL/kg bw to the nonabraded skin of 8 New Zealand White rabbits (4 males and 4 females), signs of systemic toxicity occurred (anorexia, adipsia, emaciation and decreased defecation) during the post dose observation period of 14 days. Three of eight animals were found dead on day 2 of the study. Positive gross pathologic findings were observed in four of eight of the test animals. From the data presented in the report the LD50 of CR-39 is greater than 10 mL/kg bw (11,430 mg/kg).

No acute inhalation toxicity LC50 level could be established because of one dose level tested with only 1 hour of exposure.

Justification for classification or non-classification

The classification is warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulations No 1272/2008.

DSD:Xn, R22; Harmful if swallowed;

GHS:Acute tox.oral Cat. 4