Registration Dossier
Registration Dossier
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EC number: 203-728-9 | CAS number: 110-01-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The mode of action of alkylating agents-3. The formation of 3 hydroxytetrahydrothiophene-1,1-dioxide from 1,4- dimethanesulphonyloxybutane Myleran S-B-1 alanyltetrahydrothiophenium mesylate, tetrahydrothiophene and tetrahydrothiophene-1,1-dioxide in the..
- Author:
- Roberts JJ and Warwick GP
- Year:
- 1 961
- Bibliographic source:
- Biochem. Pharmacol., 6, 217-220
- Reference Type:
- secondary source
- Title:
- Gesundheitsschadliche Arbeitsstoffe, Tetrahydrothiophen Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten (Maximale Arbeitsplatzkonzentrationen)
- Author:
- DFG (Deutsche Forschungsgemeinschaft)
- Year:
- 1 979
- Bibliographic source:
- 7th issue Henschler, D. (Ed.) VCH-Verlagsgesellschaft mbH, Weinheim.
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrahydrothiophene
- EC Number:
- 203-728-9
- EC Name:
- Tetrahydrothiophene
- Cas Number:
- 110-01-0
- Molecular formula:
- C4H8S
- IUPAC Name:
- tetrahydrothiophene
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 35S-tetrahydrothiophene
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 6-week old
- Weight at study initiation: 200g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- arachis oil
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mg in 2ml arachid oil
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- no
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- 85% of the radioactivity was excreted in the first-day'urine. No unchanged THT was detected either in the urine and in the exhaled air
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 3-hydroxytetrahydrothiophene-1,1-dioxide
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
Tetrahydrothiophene (THT) involves extensive oxidation. Tetrahydrothiophene-1,1-dioxide is formed from the sulfide, and this is then further metabolized to 3-hydroxytetrahydrothiophene-1,1-dioxide. Up to 85% of the administered dose is excreted in the urine within 24 hours.
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